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Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor-like repeats or thrombospondin type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates.
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