Invitrogen

PLAC1 Polyclonal Antibody

PLAC1 Antibody in Immunohistochemistry (IHC)

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PLAC1 Antibody (PA5-64120) in IHC

Immunohistochemical staining of PLAC1 in human placenta and prostate tissues using PLAC1 Polyclonal Antibody (Product # PA5-64120). Corresponding PLAC1 RNA-seq data are presented for the same tissues.

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PLAC1 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of PLAC1 demonstrates antibody specificity. Immunohistochemical analysis of PLAC1 using anti-PLAC1 Polyclonal Antibody (Product # PA5-64120), shows significant staining of PLAC1 in human placenta and shows minimal or weak staining in human prostate tissues. The relative expression levels of PLAC1 within each tissue is shown using RNA-Seq. {RE}

Product Details

PA5-64120

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

1:50-1:200

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PLAC1

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.10 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

AB_2645620

Product Specific Information

Immunogen sequence: GQSPMTVLCS IDWFMVTVHP FMLNNDVCVH FHELHLGLGC PPNHVQPHAY QFTYRVTECG IRA

Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 76%.

Target Information

PLAC1 was initially identified as a protein expressed specifically in the placenta and other cells derived from the trophoblast lineage during embryonic development, but has also been found to be expressed ectopically in a wide range of human malignancies, particularly breast cancers. PLAC1 is a membrane-associated protein that is thought to serve a receptor-like function modulating cell-cell or ligand receptor interactions unique to the maternal-placental interface. Decreased expression of PLAC1 is associated with decreased expression of cyclin D1 and reduced expression of AKT kinase, which, combined with the fact that PLAC1 is expressed on the surface of cancer cells, suggests that PLAC1 may be an effective candidate for immunotherapeutic treatments of cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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