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Proteintech
PI16 Polyclonal Antibody
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Product Details
12267-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PI16 Fusion Protein Ag2925 (1-300 aa encoded by BC022399)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MHGSCSFLM LLLPLLLLLV ATTGPVGALT DEEKRLMVEL HNLYRAQVSP TASDMLHMRW DEELAAFAKA YARQCVWGHN KERGRRGENL FAITDEGMDV PLAMEEWHHE REHYNLSAAT CSPGQMCGHY TQVVWAKTER IGCGSHFCEK LQGVEETNIE LLVCNYEPPG NVKGKRPYQE GTPCSQCPSG YHCKNSLCEP IGSPEDAQDL PYLVTEAPSF RATEASDSRK MGTPSSLATG IPAFLVTEVS GSLATKALPA VETQAPTSLA TKDPPSMATE APPCVTTEVP SILAAHSLPS L (1-300 aa encoded by BC022399)
Target Information
Peptidase inhibitor 16 (PI16), also known as CRISP-9 or PSPBP, is a member of the cysteine-rich secretory protein (CRISP) family and plays a significant role in various biological processes. This protein consists of 436 amino acids and features three N-linked glycosylation motifs, suggesting its localization to the plasma membrane through a GPI anchor. PI16 has been implicated as a binding protein for prostate secretory protein of 94 amino acids (PSP94), which reflects its potential involvement in reproductive biology. Recent findings highlight PI16's expression in fibroblasts, particularly marking a precursor fibroblast cell state, which is critical in fibroblast lineage development. This expression is heightened in certain pathological conditions, such as neuropathic pain and inflammatory arthritis. In neuropathic pain models such as the spared nerve injury (SNI) model, elevated PI16 levels are noted in fibroblasts within the dorsal root ganglia (DRG) and sciatic nerve, but not in neurons or glia. Interestingly, mice lacking PI16 are protected against neuropathic pain, indicating its role in enhancing pain signaling. Conversely, in rheumatoid arthritis (RA), PI16's overexpression in peripheral blood and synovial fluid correlates with worsened arthritis severity, partly by suppressing the expression of the regulatory T cell marker Foxp3. This complex role of PI16, affecting various signaling pathways and cellular states, underscores its potential as a therapeutic target in pain and inflammatory diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD364; CRISP-9; Cysteine-rich secretory protein 9; microseminoprotein, beta-binding protein; Peptidase inhibitor 16; PI-16; protease inhibitor 16; PSP94-binding protein
Gene Aliases: CD364; CRISP9; MSMBBP; PI16; PSEC0164; PSPBP; UNQ289/PRO328
UniProt ID: (Human) Q6UXB8
Entrez Gene ID: (Human) 221476
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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