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Invitrogen
PHOX2A Polyclonal Antibody
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Product Details
PA1-28070
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide FPEPSGLHEKRKQRRIR conjugated to BSA, corresponding to amino acids 78-94 of Human PHOX2A.
Conjugate
Form
Liquid
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2163590
Product Specific Information
PA1-28070 detects PHOX2A from rat, mouse, human samples.
PA1-28070 has been successfully used in immunohistochemistry, immunoprecipitation, Western blot applications.
The PA1-28070 immunogen is a synthetic peptide: FPEPSGLHEKRKQRRIR conjugated to BSA, corresponding to amino acids 78-94 of Human PHOX2A.
Target Information
PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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