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Invitrogen
PEN2 Polyclonal Antibody
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Product Details
PA1-10293
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, conjugated to KLH, corresponding to the 11 most N-terminal residues of human Pen-2.
Conjugate
Form
Lyophilized
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
This antibody is predicted to react with bovine, rat and Xenopus based on sequence homology. In addition to PEN-2, it also recognizes an unknown protein at ~40kDa.
Reconstitute using 83.3ul of sterile distilled water. After reconstitution, aliquot and store at -20C.
Target Information
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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