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Invitrogen
PAR4 Polyclonal Antibody
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Product Details
PA1-28227
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the Human C terminal region.
Conjugate
Form
Liquid
Storage conditions
4°C, do not freeze
Shipping conditions
Wet ice
RRID
AB_1959977
Product Specific Information
PA1-28227 detects PAR4 from human, mouse, rat samples.
PA1-28227 has been successfully used in immunohistochemistry (paraffin tissue) applications.
The PA1-28227 immunogen is: Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) C-terminal (Human).
Target Information
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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