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Bioss
OVCA2 Polyclonal Antibody
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FIGURE: 1 / 1
OVCA2 Antibody (BS-6298R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded rat ovary; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with Rabbit Anti-OVCA2 Polyclonal Antibody, Unconjugated (bs-6298R) at 1:500 overnight at 4°C, followed by a conjugated secondary for 90 minute... View More
Product Details
BS-6298R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human OVCA2, amino acids 11-100.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Chromosome 17 is a hotspot for chromosomal aberrations in breast and ovarian cancer. Candidate oncogenes and tumor suppressors located on this chromosome include OVCA1 and OVCA2, p53, BRCA1, HER2/neu and others. OVCA1 and 2 map to a highly conserved region on human chromosome 17p13.3 that is deleted in 80% of ovarian cancers and shows frequent loss of heterozygosity in breast cancers. OVCA1 is induced by BRCA1 and is closely linked to p53, a well-known tumor suppressor gene. The close linkage of OVCA1 and p53 suggests that coordinated loss of the two genes may lead to ovarian, breast and other tumor types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: candidate tumor suppressor in ovarian cancer 2; candidate tumor suppressor OVCA2; Esterase OVCA2; ortholog of human candidate tumor suppressor in ovarian cancer 2 OVCA2; ovarian cancer gene-2 protein; Ovarian cancer-associated gene 2 protein; Ovarian cancer-associated gene 2 protein homolog; OVCA2 serine hydrolase domain-containing protein
Gene Aliases: 9030414M07Rik; OVCA2; RGD1564623
UniProt ID: (Human) Q8WZ82, (Mouse) Q9D7E3
Entrez Gene ID: (Human) 124641, (Rat) 497954, (Mouse) 246257
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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