Product References
Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine.
Cell reports. Medicine
Dan J,Cai J,Zhong Y,Wang C,Huang S,Zeng Y,Fan Z,Xu C,Hu L,Zhang J,Hu J,Liu Y,Su X,Zhu W,Yan G,Liang J,Lin Y
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 12-5743-82) in Flow Cytometry
Tue Oct 17 00:00:00 UTC 2023
RAD21 amplification epigenetically suppresses interferon signaling to promote immune evasion in ovarian cancer.
The Journal of clinical investigation
Deng P,Wang Z,Chen J,Liu S,Yao X,Liu S,Liu L,Yu Z,Huang Y,Xiong Z,Xiao R,Gao J,Liang W,Chen J,Liu H,Hong JH,Chan JY,Guan P,Chen J,Wang Y,Yin J,Li J,Zheng M,Zhang C,Zhou P,Kang T,Teh BT,Yu Q,Zuo Z,Jiang Q,Liu J,Xiong Y,Xia X,Tan J
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 12-5743-82) in Flow Cytometry
Tue Nov 15 00:00:00 UTC 2022
ICAM-1 on Breast Cancer Cells Suppresses Lung Metastasis but Is Dispensable for Tumor Growth and Killing by Cytotoxic T Cells.
Frontiers in immunology
Regev O,Kizner M,Roncato F,Dadiani M,Saini M,Castro-Giner F,Yajuk O,Kozlovski S,Levi N,Addadi Y,Golani O,Ben-Dor S,Granot Z,Aceto N,Alon R
12-5743-82 was used in Flow cytometry/Cell sorting to indicate that ICAM-1 expressed by metastatic breast cancer cells that expand inside the lung vasculature is involved in innate rather than in adaptive cancer cell killing.
Tue Aug 02 00:00:00 UTC 2022
CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4.
Cancer cell
Liao P,Wang W,Wang W,Kryczek I,Li X,Bian Y,Sell A,Wei S,Grove S,Johnson JK,Kennedy PD,Gijón M,Shah YM,Zou W
12-5743-82 was used in Flow cytometry/Cell sorting to discover that T cell-derived interferon (IFN)γ in combination with arachidonic acid (AA) induces immunogenic tumor ferroptosis, serving as a mode of action for CD8+ T cell (CTL)-mediated tumor killing.
Mon Apr 11 00:00:00 UTC 2022
Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity.
Journal for immunotherapy of cancer
Wang Z,Xu F,Hu J,Zhang H,Cui L,Lu W,He W,Wang X,Li M,Zhang H,Xiong W,Xie C,Liu Y,Zhou P,Liu J,Huang P,Qin XF,Xia X
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 12-5743-82) in Flow Cytometry
Sat May 01 00:00:00 UTC 2021
Titrating Polyarginine into Nanofibers Enhances Cyclic-Dinucleotide Adjuvanticity in Vitro and after Sublingual Immunization.
ACS biomaterials science & engineering
Kelly SH,Cossette BJ,Varadhan AK,Wu Y,Collier JH
12-5743-82 was used in Flow cytometry/Cell sorting to present a potentially generalizable biomaterial strategy for enhancing the potency of CDN adjuvants and reveal important design considerations for the nascent field of sublingual biomaterial immunization.
Mon May 10 00:00:00 UTC 2021
β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway.
Cell
Ghosh S,Dellibovi-Ragheb TA,Kerviel A,Pak E,Qiu Q,Fisher M,Takvorian PM,Bleck C,Hsu VW,Fehr AR,Perlman S,Achar SR,Straus MR,Whittaker GR,de Haan CAM,Kehrl J,Altan-Bonnet G,Altan-Bonnet N
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 12-5743-82) in Flow Cytometry
Thu Dec 10 00:00:00 UTC 2020
Intratumoral Delivery of a PD-1-Blocking scFv Encoded in Oncolytic HSV-1 Promotes Antitumor Immunity and Synergizes with TIGIT Blockade.
Cancer immunology research
Lin C,Ren W,Luo Y,Li S,Chang Y,Li L,Xiong D,Huang X,Xu Z,Yu Z,Wang Y,Zhang J,Huang C,Xia N
12-5743 was used in Immunocytochemistry-immunoflourescence to show that locoregional oncolytic virotherapy upregulated the expression of PD-L1 in the TME, which was mediated by virus-induced type I and type II IFNs.
Fri May 01 00:00:00 UTC 2020
Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity.
Nature communications
von Roemeling CA,Wang Y,Qie Y,Yuan H,Zhao H,Liu X,Yang Z,Yang M,Deng W,Bruno KA,Chan CK,Lee AS,Rosenfeld SS,Yun K,Johnson AJ,Mitchell DA,Jiang W,Kim BYS
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 12-5743-82) in Flow Cytometry
Fri Mar 20 00:00:00 UTC 2020
The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration.
Molecular therapy. Nucleic acids
Van Hoecke L,Roose K,Ballegeer M,Zhong Z,Sanders NN,De Koker S,Saelens X,Van Lint S
12-5743-82 was used in Flow cytometry/Cell sorting to demonstrate that the opposing roles of type I type I interferon signaling on the magnitude of the vaccine-evoked T cell responses is dependent on the route of mRNA-lipoplex administration and is regulated at the level of the T cells rather than indirectly through modulation of dendritic cell function.
Fri Dec 04 00:00:00 UTC 2020
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
The Journal of clinical investigation
Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 12-5743-82) in Flow Cytometry
Tue Aug 13 00:00:00 UTC 2019
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Thu Jun 28 00:00:00 UTC 2018
Designer vaccine nanodiscs for personalized cancer immunotherapy.
Nature materials
Kuai R,Ochyl LJ,Bahjat KS,Schwendeman A,Moon JJ
12-5743 was used in Flow cytometry/Cell sorting to demonstrate that nanodiscs eliminate established MC-38 and B16F10 tumours when combined with anti-PD-1 and anti-CTLA-4 therapy.
Sat Apr 01 00:00:00 UTC 2017
Role of Lymphocyte Subsets in the Immune Response to Primary B Cell-Derived Exosomes.
Journal of immunology (Baltimore, Md. : 1950)
Saunderson SC,McLellan AD
12-5743-82 was used in Flow cytometry/Cell sorting to investigate the requirement for CD4 T cells, B cells, and NK cells to provide help for CD8 T cell-mediated response to B cell-derived exosomes.
Sun Oct 01 00:00:00 UTC 2017
Polyelectrolyte-Enrobed Cancer Cells in View of Personalized Immune-Therapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Lybaert L,Ryu KA,De Rycke R,Chon AC,De Wever O,Vermaelen KY,Esser-Kahn A,De Geest BG
12-5743 was used in Flow cytometry/Cell sorting to demonstrate the potential of polyelectrolyte-enrobed cancer cells as promoters of antigen cross-presentation.
Thu Jun 01 00:00:00 UTC 2017
A Human Trypanosome Suppresses CD8+ T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4+ Foxp3+ T Cells.
PLoS pathogens
Ersching J,Basso AS,Kalich VL,Bortoluci KR,Rodrigues MM
12-5743 was used in Flow cytometry/Cell sorting to demonstrate a newly described mechanism of CD8+ T cell priming by CD4+ Foxp3+ T cells during Trypanosoma cruzi infection.
Wed Jun 01 00:00:00 UTC 2016
Low-Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Krummey SM,Martinez RJ,Andargachew R,Liu D,Wagener M,Kohlmeier JE,Evavold BD,Larsen CP,Ford ML
12-5743 was used in Binding experiments to investigate the impact of TCR-priming affinity on memory T cell populations following a graft rechallenge.
Tue Mar 15 00:00:00 UTC 2016
Polymer nanoparticles for cross-presentation of exogenous antigens and enhanced cytotoxic T-lymphocyte immune response.
International journal of nanomedicine
Song C,Noh YW,Lim YT
12-5743 was used in Flow cytometry/Cell sorting to show that (PEI)-coated polymer nanoparticles function as efficient antigen-delivery carriers that can induce antigen cross-presentation and a strong CTL response.
Mon Feb 27 00:00:00 UTC 2017
The CD169 sialoadhesin molecule mediates cytotoxic T-cell responses to tumour apoptotic vesicles.
Immunology and cell biology
Black LV,Saunderson SC,Coutinho FP,Muhsin-Sharafaldine MR,Damani TT,Dunn AC,McLellan AD
12-5743-82 was used in Flow cytometry/Cell sorting to find that CD169(+) macrophages were the predominant splenic macrophage subset responsible for the capture of EL4 lymphoma-derived apoptotic vesicles (ApoVs) from circulation.
Sun May 01 00:00:00 UTC 2016
Monomeric annexin A2 is an oxygen-regulated toll-like receptor 2 ligand and adjuvant.
Journal for immunotherapy of cancer
Andersen BM,Xia J,Epstein AL,Ohlfest JR,Chen W,Blazar BR,Pennell CA,Olin MR
12-5743 was used in Flow cytometry/Cell sorting to study the effect of ANXA2m on CD80 and CD86 expression, antigen cross-presentation, and the secretion of various cytokines.
Wed Feb 17 00:00:00 UTC 2016
A Toll-like receptor 2 agonist-fused antigen enhanced antitumor immunity by increasing antigen presentation and the CD8 memory T cells population.
Oncotarget
Wu CC,Liu SJ,Chen HW,Shen KY,Leng CH
12-5743 was used in Flow cytometry/Cell sorting to explore the use of TLR2 agonist-fused antigens for efficient cancer therapy.
Tue May 24 00:00:00 UTC 2016
Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.
Nature biotechnology
Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ
12-5743 was used in Flow cytometry/Cell sorting to demonstrate that injected mesoporous silica rods assemble in vivo to form structures providing a 3D cellular microenvironment for host immune cells.
Thu Jan 01 00:00:00 UTC 2015
Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection.
The Journal of clinical investigation
Tzelepis F,Verway M,Daoud J,Gillard J,Hassani-Ardakani K,Dunn J,Downey J,Gentile ME,Jaworska J,Sanchez AM,Nédélec Y,Vali H,Tabrizian M,Kristof AS,King IL,Barreiro LB,Divangahi M
12-5743 was used in Flow cytometry/Cell sorting to investigate the contribution of engulfment ligands to efferocytosis in vivo.
Sun Feb 01 00:00:00 UTC 2015
Peptidylarginine deiminase inhibition impairs Toll-like receptor agonist-induced functional maturation of dendritic cells, resulting in the loss of T cell-proliferative capacity: a partial mechanism with therapeutic potential in inflammatory settings.
Journal of leukocyte biology
Jang B,Kim HW,Kim JS,Kim WS,Lee BR,Kim S,Kim H,Han SJ,Ha SJ,Shin SJ
12-5743 was used in Flow cytometry/Cell sorting to investigate how Cl-amidine has therapeutic potential for treating inflammation-mediated diseases.
Sun Feb 01 00:00:00 UTC 2015
Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
PloS one
Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 12-5743-82) in Flow Cytometry
Thu Apr 28 00:00:00 UTC 2016
The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (β2M) affecting antigen presentation function of macrophage.
PLoS pathogens
Sreejit G,Ahmed A,Parveen N,Jha V,Valluri VL,Ghosh S,Mukhopadhyay S
12-5743 was used in Flow cytometry/Cell sorting to highlight a novel mechanism by which Mycobacterium tuberculosis may undermine host adaptive immune responses.
Wed Oct 01 00:00:00 UTC 2014
The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (β2M) affecting antigen presentation function of macrophage.
PLoS pathogens
Sreejit G,Ahmed A,Parveen N,Jha V,Valluri VL,Ghosh S,Mukhopadhyay S
12-5743 was used in Flow cytometry/Cell sorting to highlight a novel mechanism by which Mycobacterium tuberculosis may undermine host adaptive immune responses.
Wed Oct 01 00:00:00 UTC 2014
Oxidized lipids block antigen cross-presentation by dendritic cells in cancer.
Journal of immunology (Baltimore, Md. : 1950)
Ramakrishnan R,Tyurin VA,Veglia F,Condamine T,Amoscato A,Mohammadyani D,Johnson JJ,Zhang LM,Klein-Seetharaman J,Celis E,Kagan VE,Gabrilovich DI
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 12-5743-82) in Flow Cytometry
Sat Mar 15 00:00:00 UTC 2014
Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Shen KY,Song YC,Chen IH,Leng CH,Chen HW,Li HJ,Chong P,Liu SJ
12-5743 was used in Western Blotting to suggest that TLR2-mediated cross-presentation occurs through the upregulation of Rab7 and a TAP-independent pathway that prime CTL responses.
Thu May 01 00:00:00 UTC 2014
CD8(+) T cell activation by murine erythroblasts infected with malaria parasites.
Scientific reports
Imai T,Ishida H,Suzue K,Hirai M,Taniguchi T,Okada H,Suzuki T,Shimokawa C,Hisaeda H
12-5743 was used in Flow cytometry/Cell sorting to examine the parasitism of erythroblasts by P. falciparum and P. vivax and the immune response towards them.
Mon Sep 16 00:00:00 UTC 2013
Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo.
Immunity
Moreau HD,Lemaître F,Terriac E,Azar G,Piel M,Lennon-Dumenil AM,Bousso P
12-5743 was used in Flow cytometry/Cell sorting to examine how T cells sense TCR ligands of varying affinities in vivo.
Fri Aug 24 00:00:00 UTC 2012
Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice.
The Journal of clinical investigation
Woller N,Knocke S,Mundt B,Gürlevik E,Strüver N,Kloos A,Boozari B,Schache P,Manns MP,Malek NP,Sparwasser T,Zender L,Wirth TC,Kubicka S,Kühnel F
12-5743 was used in Flow cytometry/Cell sorting to highlight viruses as attractive tools for eliciting effective antitumour responses upon DC vaccination.
Fri Jul 01 00:00:00 UTC 2011
The PTAP sequence within the p6 domain of human immunodeficiency virus type 1 Gag regulates its ubiquitination and MHC class I antigen presentation.
Journal of immunology (Baltimore, Md. : 1950)
Hahn S,Setz C,Wild J,Schubert U
12-5743 was used in Flow cytometry/Cell sorting to identify a naturally occurring sequence motif within Gag that regulates its entry into the defective ribosomal products pathway.
Sun May 15 00:00:00 UTC 2011
The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation.
Virology
Kwun HJ,da Silva SR,Qin H,Ferris RL,Tan R,Chang Y,Moore PS
12-5743 was used in Flow cytometry/Cell sorting to investigate the localisation of MHC I inhibiting function on the latency associated-nuclear antigen 1 from Kaposi's sarcoma-associated herpesvirus.
Sun Apr 10 00:00:00 UTC 2011
-peptide-bound-to-H-2Kb-Flow-20170216130641.jpg?time=20250104 "OVA257-264 (SIINFEKL) peptide bound to H-2Kb Antibody in Flow Cytometry (Flow)")
-peptide-bound-to-H-2Kb-Flow-20170216130641.jpg?time=20250104)
-peptide-bound-to-H-2Kb-Flow-20170216130641.jpg?time=20250104?time=20250104 "OVA257-264 (SIINFEKL) peptide bound to H-2Kb Antibody (12-5743-82) in Flow")
