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Neuromics
Neuropeptide Q3/NPQ3 Polyclonal Antibody
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Product Details
RA14134-100UL
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NH2-CGGGFISDQSRRKELADRPPPE-OH
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Target Information
Spexin hormone plays a role as a central modulator of cardiovasular and renal function and nociception. It also plays also a role in energy metabolism and storage and inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release. Spexin is cleaved into 2 chains - Spexin-1 and Spexin-2. Spexin-1 acts as a ligand for galanin receptors GALR2 and GALR3. Intracerebroventricular administration of Spexin-1 induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Spexin-1 induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of Spexin-1 induces a reduction in food consumption and body weight. Spexin-1 also inhibits long chain fatty acid uptake into adipocytes. Intracerebroventricular administration of Spexin-2 induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of Spexin-1 and 2 also induces antinociceptive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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