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Invitrogen
NRXN3 (extracellular) Polyclonal Antibody
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FIGURE: 1 / 3
NRXN3 (extracellular) Antibody (PA5-77521) in IHC
Immunohistochemistry analysis of NRXN3 (extracellular) in rat and mouse brain. A) Samples were probed with NRXN3 (extracellular) polyclonal antibody (Product # PA5-77521) using a dilution of 1:400, and incubated with DAPI. B) Neurexin 3α staining appeared in axonal processes in striatum (horizontal arrow) and in neuronal cell bodies in lateral septum (vertical arrows).
Product Details
PA5-77521
Applications
Tested Dilution
Publications
Product Specifications
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide (C)RYLRWDASTRSDLS, corresponding to amino acid residues 39-52 of rat Neurexin 3alpha
Conjugate
Form
Lyophilized
Concentration
0.85 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2736259
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of double distilled water.
Target Information
Neurexins comprise a family of neuronal cell surface proteins, which include neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3) and Caspr (neurexin IV). Neurexins I-III are expressed as a and b isoforms. The a isoforms are made of three cassettes, which contain two LNS (Laminin A, Neurexins, Sex hormone-binding)-domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal. The a isoforms bind to neurexophilins at the second LNS site and to the excitatory neurotoxin a-latrotoxin. The b isoforms have only one LNS-domain, bind to neuroligins, and play a role in the formation and remodeling of synapes. Caspr (for Contactin-Associated Protein 1, also designated Paranodin in mouse), contains an extracellular domain similar to the other three neurexins, and binds to the surface glycoprotein Contactin. Caspr and the closely related Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. Specifically, Caspr exists at the paranodal junctions, while Caspr2 colocalizes with Shaker-like K+ channels in the juxtaparanodal region. Caspr may play a role in the communication of glial cells and neurons during development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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