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Invitrogen
NOX4 Polyclonal Antibody
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FIGURE: 1 / 7
NOX4 Antibody (PA5-31914) in ICC/IF
NOX4 Polyclonal Antibody detects NOX4 protein at cytoplasm by immunofluorescent analysis. Sample: A431 cells were fixed in ice-cold MeOH for 5 min. Green: NOX4 protein stained by NOX4 Polyclonal Antibody (Product # PA5-31914) diluted at 1:500. Blue: Hoechst 33342 staining.
Product Details
PA5-31914
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein fragment corresponding to a region within amino acids 252 and 564 of Human NOX4
Conjugate
Form
Liquid
Concentration
0.96 mg/mL
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PA5-31914 targets NOX4 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-31914 immunogen is recombinant protein fragment corresponding to a region within amino acids 252 and 564 of Human NOX4.
Target Information
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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