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Invitrogen
NLRC4 Polyclonal Antibody
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FIGURE: 1 / 1
NLRC4 Antibody (PA5-72908) in IHC
Nature communications 2022 -
Fig. 2 NLRC4 is the primary inflammasome responsible for P. aeruginosa recognition and it is inhibited by ExoT. a - j BMDMs (from C57BL/6) were infected with wild-type P. aeruginosa PA103 and the indicated T3SS isogenic mutants for 1-2 h (1 h for IF microscopy and 2 h for ELISA and Western blotting). a , b Culture supernatants were assessed for IL-1beta or IL-18 by ELISA and the tabulated data are shown as ... View More
Product Details
PA5-72908
Applications
Tested Dilution
Publications
Product Specifications
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to within amino acis 610 and 660 of Ipaf/Clan/CARD12 was used as immunogen, from genbank sequence NP_067032.3
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2718762
Target Information
NLRC4 encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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