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Invitrogen
NEIL3 Polyclonal Antibody
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FIGURE: 1 / 1
NEIL3 Antibody (PA5-72424) in WB
Western blot analysis of NEIL3 in the following samples: Lane 1: HeLa cell lysate, Lane 2: HepG2 cell lysate. 20 µg of protein per lane was used. Samples were first blocked with 5% NFDM/TBST, incubated with NEIL3 polyclonal antibody (Product # PA5-72424) using a dilution of 1:1000 followed by a goat anti-rabbit IgG H&L (HRP) secondary antibody with a dilution of 1:10,000.
Product Details
PA5-72424
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
region 481 - 540 aa
Conjugate
Form
Liquid
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2718278
Target Information
DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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