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Invitrogen
NALP4 Polyclonal Antibody
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Product Details
PA5-60023
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NALP4
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2644454
Product Specific Information
Immunogen sequence: LMVSAYCLKY CSSLRKLCFS VQNVFKKEDE HSSTSDYSLI CWHHICSVLT TSGHLRELQV QDSTLSESTF VTWCNQLRHP SCRLQKLGIN NVSFSGQSVL LFEVLFYQPD L
Highest antigen sequence identity to the following orthologs: Mouse - 42%, Rat - 47%.
Target Information
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-kappa-B induction by TNF-a and IL-1-b, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-kappa-B induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-alpha and IKK-beta, suggesting that NALP4 is critical in modulating NF-kappa-B activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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