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Invitrogen
NALCN (extracellular) Polyclonal Antibody
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FIGURE: 1 / 3
NALCN (extracellular) Antibody (PA5-77736) in IHC
Immunohistochemistry analysis of NALCN (extracellular) in rat hypothalamus. A) Samples were probed with NALCN (extracellular) polyclonal antibody (Product # PA5-77736) and incubated with DAPI. B) Nuclei stained image. C) Merged image of Panels A and B.
Product Details
PA5-77736
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide (C)SMMFESPFRRVMH, corresponding to amino acid residues 902-914 of rat Sodium leak channel non-selective protein
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2736190
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
Target Information
Nalcn is a voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Nalcn regulates the resting membrane potential and controls neuronal excitability (PubMed:17448995). Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, Nalcn activity is enhanced/modulated by several GPCRs, is required for normal respiratory rhythm and neonatal survival, is involved in systemic osmoregulation by controlling the serum sodium concentration. Nalcn is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Further, Nalcn plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability. Diseases associated with NALCN include Congenital contractures of the limbs and face, Hypotonia, Developmental Delay and Hypotonia, Infantile Psychomotor Retardation And Characteristic Facies 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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