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Invitrogen
N-cadherin Polyclonal Antibody
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FIGURE: 1 / 1
N-cadherin Antibody (PA1-20359)
IP-MS enrichment of CDH2 (LFQ intensity): CDH2 was enriched 16-fold from A549 lysate compared to background proteins, using the optimized IP-MS workflow with Pierce MS-Compatible Magnetic IP Kit protein A/G (Part No. 90409) and CDH2 antibody (Part No. PA1-20359). The STRING database (www.string-db.org) was used to identify the protein interactor list. See more information on IP-MS verification of antibody s... View More
Product Details
PA1-20359
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues R(808) M D E R P I H A E P Q Y P V R S A A P(827) of human N-Cadherin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2077427
Product Specific Information
PA1-20359 detects N-Cadherin in human, mouse, and bovine samples. This antibody does not cross-react with E or P Cadherin.
PA1-20359 has been successfully used in immunohistochemistry (frozen & FFPE) and Western blot procedures.
The PA1-20359 immunogen is a synthetic peptide corresponding to residues R(808) M D E R P I H A E P Q Y P V R S A A P(827) of human N-Cadherin.
Target Information
N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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