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Immunogen sequence: KQDETLSSSE ITLWTEKQSN GDKKSIELND QKFNELIKNC NKHDGRGIIV DARQLPSPEP CEIQKNLNDN EMLFHSCQMV EESHEEEELK
Highest antigen sequence identity to the following orthologs: Mouse - 48%, Rat - 44%.
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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