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Recommended positive controls: rat embryonic brain.
PA1-24950 is expected to cross react with mouse and human due to sequence homology.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.
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