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Invitrogen
MEL18 Polyclonal Antibody
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FIGURE: 1 / 3
MEL18 Antibody (PA1-31962) in WB
Western blot was performed using Anti-MEL18 Goat Polyclonal Antibody (Product # PA1-31962) and 37 kDa band corresponding to MEL18 was observed. Uncharacterized bands at 50 and 60 kDa were observed across the cell lines tested. Modified whole cell extracts (1%SDS) (30 µg lysate) of Hep G2 (Lane1), A549 (Lane2), SH-SY5Y (Lane 3), SH-SY5Y treated with Retinoic acid (10uM for 8 Days) (Lane 4), AML-193 (Lane 5), AML-193 treated with Retinoic Acid (10uM for 2 days) (Lane 6) and AML-193 treated with Retinoic Acid (10uM for 8 days) (Lane 7) were e... View More
Product Details
PA1-31962
Product Specifications
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide KMTVNGAPVPPLT (Human).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_1956686
Product Specific Information
Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX25267-PEP)..
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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