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Invitrogen
MD-2 Monoclonal Antibody (18H10), FITC
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Product Details
MA5-49060
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
18H10
Immunogen
TLR4/MD-2 expressing CHO cells/ chimeric TLR4/MD-2 fusion protein.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
100 µg/mL
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
The monoclonal antibody 18H10 reacts with MD-2. However, it does not react with sMD-2. In addition, the monoclonal antibody 18H10 is able to inhibit bacterial binding to MD-2.
Target Information
MD-2 is a gene that encodes a protein involved in the recognition of bacterial lipopolysaccharides (LPS) by the immune system. It is located on chromosome 8 and is part of a larger family of genes that encode for similar proteins. The MD-2 protein forms a complex with Toll-like receptor 4 (TLR4) to recognize and respond to LPS, triggering an immune response. Mutations or variations in the MD-2 gene have been associated with various diseases and conditions, including sepsis and inflammatory disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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