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Invitrogen
MCM7 Polyclonal Antibody
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Product Details
PA1-26585
Product Specifications
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a portion of human Minichromosome Maintenance Deficient 7 encoded in part by exons 8 and 9.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Storage conditions
4°C, do not freeze
Shipping conditions
Wet ice
RRID
AB_2142707
Product Specific Information
PA1-26585 detects MCM7 from human samples. PA1-26585 is expected to cross react with mouse (78% conserved) due to sequence homology.
PA1-26585 has been successfully used in Western blot procedures. Predicted molecular weight: 90 kDa. Positive control: HeLa cell lysate.
The PA1-26585 immunogen is a synthetic peptide corresponding to a portion of human Minichromosome Maintenance Deficient 7 encoded in part by exons 8 and 9.
Target Information
MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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