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Invitrogen
LRRK2 Polyclonal Antibody
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FIGURE: 1 / 2
LRRK2 Antibody (PA5-111858) in IHC (F)
Immunohistochemistry analysis of LRRK2 in perfusion-fixed, frozen rat striatum and substantia nigra tissue sections using LRRK2 Antibody (Product # PA5-111858) at a dilution of 1:400, followed by goat-anti-rabbit-AlexaFluor-488 secondary antibody. A) LRKK2 staining (green) of striatum sections is detected in the cytoplasm of several striatal cells (arrows). B) Staining in the substantia nigra pars compacta ... View More
Product Details
PA5-111858
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to amino acid residues 183-196 of mouse LRRK2 (N-terminus)
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2857267
Product Specific Information
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: CKALHVLFER VSEE
Homology: Rat, human amino acid residues are identical.
Target Information
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in LRRK2 have been associated with Parkinson's disease. LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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