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Invitrogen
LRRC8A (extracellular) Polyclonal Antibody
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FIGURE: 1 / 3
LRRC8A (extracellular) Antibody (PA5-111751) in IHC (F)
Immunohistochemistry analysis of LRRC8A in perfusion-fixed, frozen mouse cerebellum and olfactory bulb tissue sections using LRRC8A (extracellular) Antibody (Product # PA5-111751) at a dilution of 1:200, followed by goat-anti-rabbit-AlexaFluor-488. A) LRRC8A staining in mouse cerebellum (green) shows intensely positive cells (arrows) with Bergmann glia morphology and localization. B) Staining in mouse olfac... View More
Product Details
PA5-111751
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to amino acid residues 91-104 of human LRRC8A (1 extracellular loop)
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2857161
Product Specific Information
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: (C)DTGPTGI KYDLDRH
Homology: Rat, mouse amino acid residues are identical.
Target Information
Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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