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Invitrogen
LRRC8A Polyclonal Antibody
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FIGURE: 1 / 2
LRRC8A Antibody (PA5-49209) in WB
Western blot analysis of LRRC8A in various lysates. Samples were incubated with LRRC8A polyclonal antibody (Product # PA5-49209) using a dilution of 1:2,000 followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at a dilution of 1:10,000. Lysates/proteins: 20 µg per lane. Lane 1: 293T/17 whole cell lysate; Lane 2: mouse kidney lysate. Predicted band size: 94 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Product Details
PA5-49209
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 782-810 amino acids from the C-terminal region of human LRRC8A.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2634665
Product Specific Information
Predicted to react with mouse and rat based on sequence homology.
Target Information
Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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