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Invitrogen
LRRC4B (extracellular) Polyclonal Antibody
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FIGURE: 1 / 3
LRRC4B (extracellular) Antibody (PA5-111864) in IHC (F)
Immunohistochemistry analysis of LRRC4B in perfusion-fixed, frozen mouse hippocampus tissue sections using LRRC4B (extracellular) Antibody (Product # PA5-111864) at a dilution of 1:200, followed by goat anti-rabbit-AlexaFluor-488. NGL-3 immunoreactivity (green) is detected in the pyramidal layer (arrows). Cell nuclei are stained with DAPI (blue).
Product Details
PA5-111864
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to amino acid residues 498-511 of mouse NGL-3 (Extracellular, N-terminus)
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2857273
Product Specific Information
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: (C)PGEEAQQ PRGTEKE
Homology: Rat amino acid residues identical; human - 13 out of 14 amino acid residues identical.
Target Information
The LRRC4B gene encodes a protein known as leucine-rich repeat-containing protein 4B, which is involved in cellular signaling and neural development. LRRC4B is a member of the leucine-rich repeat (LRR) protein family, characterized by its ability to mediate protein-protein interactions through its LRR domains. This protein is predominantly expressed in the nervous system and plays a crucial role in neuronal growth, synapse formation, and signal transduction pathways essential for brain development and function. LRRC4B contributes to cell adhesion, growth cone guidance, and synaptic plasticity, influencing the formation and maintenance of neural circuits. Its dysregulation has been linked to neurodevelopmental disorders, highlighting its importance in cognitive functions and neurological health. Additionally, LRRC4B is implicated in cancer biology, where it may act as a tumor suppressor, modulating cellular proliferation and migration. Research continues to explore LRRC4B's interactions and regulatory mechanisms, offering insights into potential therapeutic applications for neurological diseases and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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