Invitrogen

LRGUK Polyclonal Antibody

Product Details

PA5-22179

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

Immunocytochemistry (ICC/IF)

1:100-1:1,000

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fragment corresponding to a region within amino acids 475 and 779 of FLJ32786 (Uniprot ID#Q96M69)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

AB_11153639

Product Specific Information

PA5-22179 targets FLJ32786 in IF and WB applications and shows reactivity with Human samples.

The PA5-22179 immunogen is a recombinant fragment corresponding to a region within amino acids 475 and 779 of FLJ32786 (Uniprot ID#Q96M69).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Target Information

The LRGUK (Leucine-Rich Repeat and Guanylate Kinase-Like Domain Containing 1) gene encodes a protein that plays a critical role in male fertility. It is particularly important for the proper function of the manchette, a microtubule-based structure involved in sperm head shaping and tail formation during spermiogenesis. Research has shown that LRGUK1 is part of a multiprotein complex essential for the initiation of sperm tail growth from the centriole/basal body. Mutations or disruptions in the LRGUK1 gene can lead to defective manchette function, resulting in abnormal sperm morphology and infertility. This gene's role in spermatogenesis underscores its importance in reproductive health, with ongoing studies aimed at elucidating its specific interactions and mechanisms within the manchette complex.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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