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Invitrogen
LGMN Polyclonal Antibody
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Product Details
PA5-64868
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human LGMN
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2664511
Product Specific Information
Immunogen sequence: QGMKRKASSPV PLPPVTHLDL TPSPDVPLTI MKRKLMNTND LEESRQLTEE IQRHLDARHL IEKSVRKIVS LLAASEAEVE QLLSERAPLT GHSCYPEALL HFRTHCFNWH SPTYEYALRH LYVLVNLCEK PYPLHRIKLS MDHVCLGHY
Highest antigen sequence identity to the following orthologs - mouse 70%, rat 69%.
Target Information
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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