Invitrogen

Kindlin Polyclonal Antibody

Product Details

PA1-4360

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide: V(643) H E Y I G G Y I F L S T R S K D Q(660)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

AB_2278289

Product Specific Information

PA1-4360 detects the URP1 protein in human samples.

PA1-4360 has been successfully used in Western blot procedures.

PA1-4360 immunizing peptide corresponds to amino acid residues 643-660 of the 77 kDa human URP1 protein. The sequence is 100% conserved between mouse, rat, canine, bovine, chimpanzee, and Xenopus.

Target Information

Kindlin 1 is a member of the kindlin family of focal adhesion proteins and contains a FERM domain and pleckstrin homology domain. It is involved in integrin signaling, linkage of the cytoskeleton to the extracellular matrix, and cell adhesion. It is most often expressed in epithelial cells. When kindlin 1 is coexpressed with talin it helps to activate ITGA2B. It is required for keratinocyte proliferation, polarization of basal keratinocytes in the skin, and for normal cell shape. Mutations in kindlin 1 have been linked to Kindler syndrome, a recessive skin disorder involving blistering, photosensitivity, poikiloderma, and atrophy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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