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PA1-4136 detects FKLF in human samples.
PA1-4136 has been successfully used in Western blot procedures. By Western blot this antibody detects FKLF in human fetal liver tissue and K562 erythroid cell line.
The PA1-4136 immunogen is a synthetic peptide corresponding to residues E(26) R K R H D S E R S T(36) of human FKLF.
The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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