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Invitrogen
KCNMA1 Polyclonal Antibody
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FIGURE: 1 / 3
KCNMA1 Antibody (PA5-111800) in WB
Western Blot analysis of KCNMA1 was performed in human Colo205 colon adenocarcinoma (lanes 1 and 3) and human Caco-2 colon adenocarcinoma cell lysates (lanes 2 and 4). Lane 1,2: KCNMA1 Antibody (Product # PA5-111800) at a dilution of 1:200. Lane 3,4: KCNMA1 Antibody preincubated with the negative control antigen.
Product Details
PA5-111800
Product Specifications
Host/Isotype
Guinea pig
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GST fusion protein corresponding to residues 1097-1196 of mouse KCNMA1variant 2 (Intracellular, C-terminus)
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2857209
Product Specific Information
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
GST fusion protein sequence is: SHSSHSSQS SSKKSSSVHS IPSTANRPNR PKSRESRDKQ NATRMTRMGQ AEKKWFTDEP DNAYPRNIQI KPMSTHMANQ INQYKSTSSL IPPIREVEDE C
Homology: Mouse - 21/21 amino acid residues identical to the canonical sequence (AccessionQ08460); rat - 20/21 amino acid residues identical to the canonical sequence (AccessionQ62976); human - 19/21 amino acid residues identical to the canonical sequence (AccessionQ12791).
Target Information
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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