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Invitrogen
KCNK16 (extracellular) Polyclonal Antibody
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FIGURE: 1 / 2
KCNK16 (extracellular) Antibody (PA5-111887) in WB
Western Blot analysis of TALK-1 was performed in human PANC-1 pancreas ductal adenocarcinoma cell line lysate. Lane 1: KCNK16 (extracellular) Antibody (Product # PA5-111887) at a dilution of 1:600. Lane 2: KCNK16 (extracellular) Antibody preincubated with the negative control antigen.
Product Details
PA5-111887
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to amino acid residues 75-88 of human KCNK16 (1st extracellular loop)
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2857295
Product Specific Information
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: (C)EAWVKGV NPKGNST
Homology: Rat, mouse amino acid residues are identical.
Target Information
The KCNK16 gene encodes the TALK-1 channel, an abundant K+ channel transcript found in mouse and in human Beta-cells. There are four human TALK-1 transcript variants, including two that form functional K+ channels (TALK-1a (transcript variant 2) and TALK1-b (transcript variant 3). The TALK-1 structure includes 4 transmembrane domains, 2 extracellular loops, and intracellular N- and C-termini. The C-terminal tail of TALK-1 is a critical component that influences the magnitude of TALK-1 channel activation, while the N-terminus is important for protein interaction. TALK-1, two-pore domain K+ (K2p 16.1) channel is responsible for modulating glucose stimulated insulin secretion that relies on Beta-cell CA2+ influx. The channel produces outwardly rectifying, non-inactivating K+ currents, which are enhanced by elevations in extracellular pH. TALK-1 is thus pH-sensitive, with increased activity under alkaline conditions. In addition, it can be activated by singlet oxygen and nitric oxide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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