Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
ITPRIPL1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
PA5-53692
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ITPRIPL1
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2642829
Product Specific Information
Immunogen sequence: PVTSYNWLTD FPSQEALDSF YKHYVQNAIR DLPCTCEFVE SFVDDLIEAC RVLSRQEAHP QLEDCLGIGA AFEKWGTLHE TQKFDILVPI VPPQGTMFVL EMRDPALGRR CGCVLVESEC VCKREKLLGD VL
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 90%.
Target Information
The ITPRIPL1 (Inositol 1,4,5-Trisphosphate Receptor Interacting Protein-Like 1) gene encodes a protein implicated in T cell regulation by interacting with the CD3e molecule. It is located on chromosome 6. The ITPRIPL1 protein acts as an inhibitory ligand for CD3e, thereby modulating T cell activation in the tumor microenvironment. This interaction significantly reduces calcium influx and phosphorylation of ZAP70, which are critical steps in the T cell activation pathway. The downregulation of these processes by ITPRIPL1 suggests its role in immune response modulation and tumor immune evasion. Given its regulatory functions, ITPRIPL1 has become a subject of research for its potential implications in cancer immunotherapy and as a biomarker for diagnosing and prognosticating various cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support