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Invitrogen
IL1R2 Polyclonal Antibody, Alexa Fluor™ 488
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Product Details
PA5-46897
Product Specifications
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Sf 21-derived recombinant mouse IL-1 RII Phe14-Glu355 (predicted)
Conjugate
Excitation/Emission Max
499/520 nm
View spectra
Form
Liquid
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Wet ice
RRID
AB_2609073
Product Specific Information
In direct ELISAs, approximately 10% cross-reactivity with recombinant human IL-1 RII is observed and less than 1% cross-reactivity with recombinant mouse (rm) IL-1 RI, recombinant rat IL-1 Rrp2, rmIL-18 R, and rmIL-18 R beta is observed.
Target Information
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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