Product References
2'-O-Methylation of the second transcribed nucleotide within the mRNA 5' cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion.
Nucleic acids research
Drazkowska K,Tomecki R,Warminski M,Baran N,Cysewski D,Depaix A,Kasprzyk R,Kowalska J,Jemielity J,Sikorski PJ
Published figure using IFIT1 polyclonal antibody (Product # PA3-848) in Western Blot
Fri Sep 09 00:00:00 UTC 2022
USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING.
Cell death & disease
Karlowitz R,Stanifer ML,Roedig J,Andrieux G,Bojkova D,Bechtel M,Smith S,Kowald L,Schubert R,Boerries M,Cinatl J,Boulant S,van Wijk SJL
PA3-848 was used in Western Blotting to reveal USP22 as central host regulator of STING and type III IFN signaling, with important implications for SARS-CoV-2 infection and antiviral defense.
Sat Aug 06 00:00:00 UTC 2022
USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING.
Cell death & disease
Karlowitz R,Stanifer ML,Roedig J,Andrieux G,Bojkova D,Bechtel M,Smith S,Kowald L,Schubert R,Boerries M,Cinatl J,Boulant S,van Wijk SJL
PA3-848 was used in Western Blotting to reveal USP22 as central host regulator of STING and type III IFN signaling, with important implications for SARS-CoV-2 infection and antiviral defense.
Sat Aug 06 00:00:00 UTC 2022
MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells.
Cell reports
Yin X,Riva L,Pu Y,Martin-Sancho L,Kanamune J,Yamamoto Y,Sakai K,Gotoh S,Miorin L,De Jesus PD,Yang CC,Herbert KM,Yoh S,Hultquist JF,García-Sastre A,Chanda SK
Published figure using IFIT1 polyclonal antibody (Product # PA3-848) in Western Blot
Tue Jan 12 00:00:00 UTC 2021
Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses.
iScience
Banerjee A,El-Sayes N,Budylowski P,Jacob RA,Richard D,Maan H,Aguiar JA,Demian WL,Baid K,D'Agostino MR,Ang JC,Murdza T,Tremblay BJ,Afkhami S,Karimzadeh M,Irving AT,Yip L,Ostrowski M,Hirota JA,Kozak R,Capellini TD,Miller MS,Wang B,Mubareka S,McGeer AJ,McArthur AG,Doxey AC,Mossman K
PA3-848 was used in Western Blot to demonstrate that SARS-CoV-2 infection induces a type I IFN response in vitro and in moderate cases of COVID-19.
Fri May 21 00:00:00 UTC 2021
Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses.
iScience
Banerjee A,El-Sayes N,Budylowski P,Jacob RA,Richard D,Maan H,Aguiar JA,Demian WL,Baid K,D'Agostino MR,Ang JC,Murdza T,Tremblay BJ,Afkhami S,Karimzadeh M,Irving AT,Yip L,Ostrowski M,Hirota JA,Kozak R,Capellini TD,Miller MS,Wang B,Mubareka S,McGeer AJ,McArthur AG,Doxey AC,Mossman K
PA3-848 was used in Western Blot to demonstrate that SARS-CoV-2 infection induces a type I IFN response in vitro and in moderate cases of COVID-19.
Fri May 21 00:00:00 UTC 2021
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.
Nature microbiology
Liu G,Lee JH,Parker ZM,Acharya D,Chiang JJ,van Gent M,Riedl W,Davis-Gardner ME,Wies E,Chiang C,Gack MU
PA3-848 was used in Immunoprecipitation, Western Blot to investigate the role of interferon (IFN)-stimulated gene 15 in innate immunity.
Thu Apr 01 00:00:00 UTC 2021
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.
Nature microbiology
Liu G,Lee JH,Parker ZM,Acharya D,Chiang JJ,van Gent M,Riedl W,Davis-Gardner ME,Wies E,Chiang C,Gack MU
PA3-848 was used in Immunoprecipitation, Western Blot to investigate the role of interferon (IFN)-stimulated gene 15 in innate immunity.
Thu Apr 01 00:00:00 UTC 2021
The E3 Ubiquitin-Protein Ligase Cullin 3 Regulates HIV-1 Transcription.
Cells
Langer S,Yin X,Diaz A,Portillo AJ,Gordon DE,Rogers UH,Marlett JM,Krogan NJ,Young JAT,Pache L,Chanda SK
PA3-848 was used in Western Blotting to indicate that Cul3 is a negative regulator of HIV-1 transcription which governs productive viral replication in infected cells.
Tue Sep 01 00:00:00 UTC 2020
The E3 Ubiquitin-Protein Ligase Cullin 3 Regulates HIV-1 Transcription.
Cells
Langer S,Yin X,Diaz A,Portillo AJ,Gordon DE,Rogers UH,Marlett JM,Krogan NJ,Young JAT,Pache L,Chanda SK
PA3-848 was used in Western Blotting to indicate that Cul3 is a negative regulator of HIV-1 transcription which governs productive viral replication in infected cells.
Tue Sep 01 00:00:00 UTC 2020
Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
The Journal of biological chemistry
Mears HV,Sweeney TR
PA3-848 was used in Western Blotting to find that Ifit1b preferentially binds to cap1-RNA, whereas binding is much weaker to cap0- and cap2-RNA.
Fri Dec 18 00:00:00 UTC 2020
Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
The Journal of biological chemistry
Mears HV,Sweeney TR
PA3-848 was used in Western Blotting to find that Ifit1b preferentially binds to cap1-RNA, whereas binding is much weaker to cap0- and cap2-RNA.
Fri Dec 18 00:00:00 UTC 2020
ISG15-dependent Activation of the RNA Sensor MDA5 and its Antagonism by the SARS-CoV-2 papain-like protease.
bioRxiv : the preprint server for biology
Liu G,Lee JH,Parker ZM,Acharya D,Chiang JJ,van Gent M,Riedl W,Davis-Gardner ME,Wies E,Chiang C,Gack MU
PA3-848 was used in Western Blotting to demonstrate interferon-stimulated gene ISG15 is crucial for the ability of viral RNA sensor MDA5 to perform an antiviral response.
Tue Oct 27 00:00:00 UTC 2020
Human IFIT proteins inhibit lytic replication of KSHV: A new feed-forward loop in the innate immune system.
PLoS pathogens
Li D,Swaminathan S
PA3-848 was used in Western Blotting to study the effects of Kaposi's sarcoma-associated herpesvirus lytic replication on IFIT expression in epithelial cells.
Fri Feb 01 00:00:00 UTC 2019
The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation.
PLoS pathogens
Wu N,Nguyen XN,Wang L,Appourchaux R,Zhang C,Panthu B,Gruffat H,Journo C,Alais S,Qin J,Zhang N,Tartour K,Catez F,Mahieux R,Ohlmann T,Liu M,Du B,Cimarelli A
Published figure using IFIT1 polyclonal antibody (Product # PA3-848) in Western Blot
Tue Oct 01 00:00:00 UTC 2019
Temporal Proteomic Analysis of BK Polyomavirus Infection Reveals Virus-Induced G2 Arrest and Highly Effective Evasion of Innate Immune Sensing.
Journal of virology
Caller LG,Davies CTR,Antrobus R,Lehner PJ,Weekes MP,Crump CM
Published figure using IFIT1 polyclonal antibody (Product # PA3-848) in Western Blot
Thu Aug 15 00:00:00 UTC 2019
Type III interferon signaling restricts enterovirus 71 infection of goblet cells.
Science advances
Good C,Wells AI,Coyne CB
PA3-848 was used in Immunocytochemistry-immunoflourescence to define the early events associated with enterovirus 71 infections of the human intestinal epithelium.
Fri Mar 01 00:00:00 UTC 2019
Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist.
Cell reports
Soday L,Lu Y,Albarnaz JD,Davies CTR,Antrobus R,Smith GL,Weekes MP
PA3-848 was used in Western Blotting to identify protein C6 as being necessary and sufficient for proteasomal degradation of HDAC5.
Tue May 07 00:00:00 UTC 2019
IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.
Nucleic acids research
Fleith RC,Mears HV,Leong XY,Sanford TJ,Emmott E,Graham SC,Mansur DS,Sweeney TR
Published figure using IFIT1 polyclonal antibody (Product # PA3-848) in Western Blot
Fri Jun 01 00:00:00 UTC 2018
The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling.
Journal of virology
Chiang C,Pauli EK,Biryukov J,Feister KF,Meng M,White EA,Münger K,Howley PM,Meyers C,Gack MU
PA3-848 was used in Western Blotting to study the human papillomavirus 16 E6 oncoprotein mediated antagonisation of activation of cytoplasmic Retinoic acid-inducible gene-I.
Thu Mar 15 00:00:00 UTC 2018
Hepatitis E virus persists in the presence of a type III interferon response.
PLoS pathogens
Yin X,Li X,Ambardekar C,Hu Z,Lhomme S,Feng Z
Published figure using IFIT1 polyclonal antibody (Product # PA3-848) in Western Blot
Mon May 01 00:00:00 UTC 2017
A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses.
mBio
Pryke KM,Abraham J,Sali TM,Gall BJ,Archer I,Liu A,Bambina S,Baird J,Gough M,Chakhtoura M,Haddad EK,Kirby IT,Nilsen A,Streblow DN,Hirsch AJ,Smith JL,DeFilippis VR
PA3-848 was used in Western Blotting to demonstrate that a novel agonist of the TRIF pathway is capable of eliciting cellular responses that are predictive of establishment of adaptive immunity.
Tue May 02 00:00:00 UTC 2017
A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses.
mBio
Pryke KM,Abraham J,Sali TM,Gall BJ,Archer I,Liu A,Bambina S,Baird J,Gough M,Chakhtoura M,Haddad EK,Kirby IT,Nilsen A,Streblow DN,Hirsch AJ,Smith JL,DeFilippis VR
PA3-848 was used in Western Blotting to demonstrate that a novel agonist of the TRIF pathway is capable of eliciting cellular responses that are predictive of establishment of adaptive immunity.
Tue May 02 00:00:00 UTC 2017
Replication of Human Norovirus RNA in Mammalian Cells Reveals Lack of Interferon Response.
Journal of virology
Qu L,Murakami K,Broughman JR,Lay MK,Guix S,Tenge VR,Atmar RL,Estes MK
PA3848 was used in western blot to assess the effect of the IFN response on human noroviruses
Sat Oct 01 00:00:00 UTC 2016
Replication of Human Norovirus RNA in Mammalian Cells Reveals Lack of Interferon Response.
Journal of virology
Qu L,Murakami K,Broughman JR,Lay MK,Guix S,Tenge VR,Atmar RL,Estes MK
PA3848 was used in western blot to assess the effect of the IFN response on human noroviruses
Sat Oct 01 00:00:00 UTC 2016
Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses.
PLoS pathogens
Sali TM,Pryke KM,Abraham J,Liu A,Archer I,Broeckel R,Staverosky JA,Smith JL,Al-Shammari A,Amsler L,Sheridan K,Nilsen A,Streblow DN,DeFilippis VR
PA3-848 was used in western blot to identify small molecules that activate the type I interferon response via IFN regulatory factor 3
Tue Dec 01 00:00:00 UTC 2015
Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses.
PLoS pathogens
Sali TM,Pryke KM,Abraham J,Liu A,Archer I,Broeckel R,Staverosky JA,Smith JL,Al-Shammari A,Amsler L,Sheridan K,Nilsen A,Streblow DN,DeFilippis VR
PA3-848 was used in western blot to identify small molecules that activate the type I interferon response via IFN regulatory factor 3
Tue Dec 01 00:00:00 UTC 2015
hTERT extends the life of human fibroblasts without compromising type I interferon signaling.
PloS one
Smith MC,Goddard ET,Perusina Lanfranca M,Davido DJ
PA3-848 was used in western blot to study the use of human telomerase reverse transcriptase to prolong the life of human fibroblasts whilst retaining their suitability for studying viral replication
Tue Dec 03 00:00:00 UTC 2013
