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PA1-29863 detects Histone H2A from human samples. PA1-29863 is expected to cross react with mouse, rat, Xenopus laevis, C. elegans, chicken and Drosphila samples.
PA1-29863 has been successfully used in Western blot applications. Suggested positive controls for this product are Human peripheral blood cell lysates or Jurkat cell lysate.
The PA1-29863 immunogen is Synthetic peptides SGRGK and RHLQLAIRNDEELNKL, corresponding to amino acids 1-5 and 81-96 of Human Histone H2A.
Store at 4°C short term. For extended storage, aliquot and store at -20°C, avoiding freeze/thaw cycles.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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