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Hox genes play a fundamental role in the development of the vertebrate central nervous system, heart, axial skeleton, limbs, gut, urogenital tract and external genitalia. HoxA2 protein may contribute to dorsal-ventral patterning and/or to the specification of neuronal phenotype. HoxA7 functions as a potent transcriptional repressor and its action as such requires several domains, including both activator and repressor regions. HoxA7 is expressed in the fetal liver, lung, skeletal muscle, kidney, pancreas and placenta.
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