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Proteintech
HLA-DQB2 Polyclonal Antibody
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Product Details
17315-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HLA-DQB2 Fusion Protein Ag11284 (1-231 aa encoded by BC031995)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSWKMALQI PGGFWAAAVT VMLVMLSTPV AEARDFPKDF LVQFKGMCYF TNGTERVRGV ARYIYNREEY GRFDSDVGEF QAVTELGRSI EDWNNYKDFL EQERAAVDKV CRHNYEAELR TTLQRQVEPT VTISPSRTEA LNHHNLLVCS VTDFYPAQIK VQWFRNDQEE TAGVVSTSLI RNGDWTFQIL VMLEITPQRG DIYTCQVEHP SLQSPITVEW RPRGPPPAGL LH (1-231 aa encoded by BC031995)
Target Information
HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB)); HLA class II histocompatibility antigen, DQ beta 2 chain; HLA class II histocompatibility antigen, DX beta chain; major histocompatibility complex, class II, DQ beta 1; MHC class II antigen DQB2
Gene Aliases: HLA-DQB1; HLA-DQB2; HLA-DXB
UniProt ID: (Human) P05538
Entrez Gene ID: (Human) 3120
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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