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Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: H2B histone family, member E; H2B/e; histone 1, H2bm; Histone H2B type 1-M; Histone H2B.e; Histone H2Be
Gene Aliases: dJ160A22.3; H2B/e; H2BC14; H2BFE; HIST1H2BM
UniProt ID: (Human) Q99879
Entrez Gene ID: (Human) 8342
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