Invitrogen

HHV-1 US3 Polyclonal Antibody

Product Details

PA5-67986

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

Product Specifications

Species Reactivity

Virus

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthesized peptide derived from human KR1_HHV11.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2691523

Target Information

US3 is a multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and inhibition of apoptosis. It phosphorylates UL31 and UL34, two critical regulators of capsid budding from nucleus to endoplasmic reticulum, thereby facilitating virion egress. US3 modulates and redistributes host components of the nuclear envelope, including LMNA, emerin/EMD and the nuclear matrix protein MATR3. It also phosphorylates envelope glycoprotein B (gB), probably to direct it to the cell surface, and promotes virus intracellular spread by restructuring host cell cytoskeleton. US3 blocks host apoptosis to extend cell survival and allow efficient viral replication. Promotes viral gene expression by phosphorylating host HDAC2 to reduce viral genome silencing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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