Invitrogen

HHLA2 Polyclonal Antibody

HHLA2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HHLA2 Antibody (PA5-63134) in IHC (P)

Immunohistochemical analysis of HHLA2 in human kidney using HHLA2 Polyclonal Antibody (Product # PA5-63134) shows weak cytoplasmic positivity in cells in tubules.

HHLA2 Antibody in Immunohistochemistry (IHC)

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HHLA2 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of HHLA2 demonstrates antibody specificity. Immunohistochemical analysis of HHLA2 using anti-HHLA2 Polyclonal Antibody (Product # PA5-63134), shows significant staining of HHLA2 in human colon and shows minimal or weak staining in human liver tissues. The relative expression levels of HHLA2 within each tissue is shown using RNA-Seq. {RE}

Product Details

PA5-63134

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

Immunohistochemistry (IHC)

1:200-1:500

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human HHLA2

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

AB_2642425

Product Specific Information

Immunogen sequence: IFPLAFFTYV PMNEQIVIGR LDEDIILPSS FERGSEVVIH WKYQDSYKVH SYYKGSDHLE SQDPRYANRT SLFYNEIQNG NASL

Highest antigen sequence identity to the following orthologs: Mouse - 32%, Rat - 33%.

Target Information

B7-H7 (also known as HHLA2) is a membrane protein with three Ig-like domains (IgV-IgC-IgV), whereas other members of the B7 family generally have only two Ig domains (IgV-IgC). B7-H7 is somewhat more closely related to B7-H3 and B7-H4 and shares 10% to 18% amino acid identity and 23% to 33% similarity to B7 family members. B7-H7 protein is widely expressed in epithelium cells of the gallbladder, breast, kidney, colon, small intestines and placenta. In the immune system, HHLA2 protein is not constitutively expressed on human monocytes/macrophages. B7-H7 is widely expressed in cancers, especially in triple negative breast cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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