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Immunogen sequence: IPASPSRTKI PAEKESHRDV LPDKPAPGAV NVPAAGSHLG QGKRAIPVPN KLGLKKTLLK APGSTSNLAR KSSSGPVWSG ASSACTSPAV GKAKSSE
Highest antigen sequence identity to the following orthologs: Mouse - 56%, Rat - 57%.
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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