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PA1-24707 detects TFIII from human samples. PA1-24707 is expected to cross react with mouse (100% conserved) due to sequence homology.
PA1-24707 has been successfully used in Western blot procedures.
The PA1-24707 immunogen is a synthetic peptide corresponding to a portion of human general transcription factor II-I encoded within exons 27 and 28 (LocusLink ID 2969).
This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11. 23. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7, 13 and 21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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