Invitrogen

GREM1 Polyclonal Antibody

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GREM1 Antibody (PA5-13123) in WB

Western blot analysis using a GREMLIN polyclonal antibody (Product # PA5-13123) in mouse liver cell lysate. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

GREM1 Antibody in Immunohistochemistry (IHC)

GREM1 Antibody in Western Blot, ELISA (WB, ELISA)

Product Image Gallery

Product Details

PA5-13123

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

ELISA (ELISA)

View 1 publication 1 publication

Product Specifications

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 147-175 amino acids from the C-terminal region of human GREMLIN

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

AB_2113287

Product Specific Information

This antibody is predicted to react with rat based on sequence homology.

Target Information

In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1.

Respiratory research

Jin J,Togo S,Kadoya K,Tulafu M,Namba Y,Iwai M,Watanabe J,Nagahama K,Okabe T,Hidayat M,Kodama Y,Kitamura H,Ogura T,Kitamura N,Ikeo K,Sasaki S,Tominaga S,Takahashi K

PA5-13123 was used in Western Blotting to study the effects of pirfenidone in lung fibroblasts isolated from fibrotic human lung tissues after TGF-Β1 exposure. Additionally, the ability of two new pharmacological targets of pirfenidone, collagen triple helix repeat containing protein 1(CTHRC1) and four-and-a-half LIM domain protein 2 (FHL2), to mediate contraction of collagen gels and migration toward fibronectin were assessed in vitro. Western blot analysis was carried out.

Tue Jun 11 00:00:00 UTC 2019

Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1.

Respiratory research

Jin J,Togo S,Kadoya K,Tulafu M,Namba Y,Iwai M,Watanabe J,Nagahama K,Okabe T,Hidayat M,Kodama Y,Kitamura H,Ogura T,Kitamura N,Ikeo K,Sasaki S,Tominaga S,Takahashi K

Tue Jun 11 00:00:00 UTC 2019

Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension.

International journal of molecular sciences

Kudryashova TV,Shen Y,Pena A,Cronin E,Okorie E,Goncharov DA,Goncharova EA

Published figure using GREM1 polyclonal antibody (Product # PA5-13123) in ELISA

Fri Sep 28 00:00:00 UTC 2018

International journal of molecular sciences

Kudryashova TV,Shen Y,Pena A,Cronin E,Okorie E,Goncharov DA,Goncharova EA

Published figure using GREM1 polyclonal antibody (Product # PA5-13123) in ELISA

Fri Sep 28 00:00:00 UTC 2018

REST upregulates gremlin to modulate diffuse intrinsic pontine glioma vasculature.

Oncotarget

Shaik S,Kennis B,Maegawa S,Schadler K,Yanwen Y,Callegari K,Lulla RR,Goldman S,Nazarian J,Rajaram V,Fangusaro J,Gopalakrishnan V

Published figure using GREM1 polyclonal antibody (Product # PA5-13123) in Immunohistochemistry

Fri Jan 12 00:00:00 UTC 2018

BMP signalling in human fetal ovary somatic cells is modulated in a gene-specific fashion by GREM1 and GREM2.

Molecular human reproduction

Bayne RA,Donnachie DJ,Kinnell HL,Childs AJ,Anderson RA

PA5-13123 was used in western blot examine the impact of bone morphogenetic protein signaling on the fate and function of ovarian somatic cells

Thu Sep 01 00:00:00 UTC 2016

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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