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Invitrogen
GNAS Polyclonal Antibody
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FIGURE: 1 / 4
GNAS Antibody (PA5-71778) in ICC/IF
Immunofluorescent analysis of GNAS in 293 cells using confocal microscopy. Samples were incubated with GNAS H1 polyclonal antibody (Product # PA5-71778) followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green) as a secondary antibody. Nuclei were counterstained with DAPI (blue).
Product Details
PA5-71778
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 287-315 amino acids from the C-terminal region of human GNAS
Conjugate
Form
Liquid
Concentration
0.42 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2717632
Target Information
Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5' exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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