Product References
Identification of a forkhead box protein transcriptional network induced in human neutrophils in response to inflammatory stimuli.
Frontiers in immunology
Ismailova A,Salehi-Tabar R,Dimitrov V,Memari B,Barbier C,White JH
14-9161-73 was used in Flow cytometry/Cell sorting to reveal a role for the FOXP4 transcription network as a regulator of responses to inflammatory stimuli in neutrophils.
Mon Feb 13 00:00:00 UTC 2023
Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies.
Immunity
Pushparaj P,Nicoletto A,Sheward DJ,Das H,Castro Dopico X,Perez Vidakovics L,Hanke L,Chernyshev M,Narang S,Kim S,Fischbach J,Ekström S,McInerney G,Hällberg BM,Murrell B,Corcoran M,Karlsson Hedestam GB
14-9161-73 was used in Flow cytometry/Cell sorting to demonstrate that polymorphisms in IGH genes can influence the function of SARS-CoV-2 neutralizing antibodies.
Tue Jan 10 00:00:00 UTC 2023
Occlusion preconditioned mice are resilient to hypobaric hypoxia-induced myocarditis and arrhythmias due to enhanced immunomodulation, metabolic homeostasis, and antioxidants defense.
Frontiers in immunology
Adzika GK,Mprah R,Rizvi R,Adekunle AO,Ndzie Noah ML,Wowui PI,Adzraku SY,Adu-Amankwaah J,Wang F,Lin Y,Fu L,Liu X,Xiang J,Sun H
14-9161-73 was used in Flow cytometry/Cell sorting to demonstrate that OP is a potent alternative therapeutic intervention for preventing hypoxia-induced myocarditis, cardiac remodeling, arrhythmias, and cardiometabolic disorders and could potentially ameliorate the progression of other inflammatory, metabolic, and oxidative stress-related diseases.
Tue Mar 07 00:00:00 UTC 2023
Combinatorial multimer staining and spectral flow cytometry facilitate quantification and characterization of polysaccharide-specific B cell immunity.
Communications biology
Hoving D,Marques AHC,Huisman W,Nosoh BA,de Kroon AC,van Hengel ORJ,Wu BR,Steenbergen RAM,van Helden PM,Urban BC,Dhar N,Ferreira DM,Kwatra G,Hokke CH,Jochems SP
14-9161-73 was used in Flow Cytometry to analyse antigen-specific B cells using combinatorial staining with fluorescently-labelled capsular polysaccharide multimers.
Sat Oct 28 00:00:00 UTC 2023
BRCA1 deficiency in mature CD8+ T lymphocytes impairs antitumor immunity.
Journal for immunotherapy of cancer
Wu B,Qi L,Chiang HC,Pan H,Zhang X,Greenbaum A,Stark E,Wang LJ,Chen Y,Haddad BR,Clagett D,Isaacs C,Elledge R,Horvath A,Hu Y,Li R
14-9161-73 was used in Flow cytometry/Cell sorting to report that mouse Brca1 knockout (KO) in mature T lymphocytes compromises host antitumor immune response to transplanted syngeneic mouse mammary tumors.
Wed Feb 01 00:00:00 UTC 2023
Inhibition of pro-inflammatory signaling in human primary macrophages by enhancing arginase-2 via target site blockers.
Molecular therapy. Nucleic acids
Fitzsimons S,Muñoz-San Martín M,Nally F,Dillon E,Fashina IA,Strowitzki MJ,Ramió-Torrentà L,Dowling JK,De Santi C,McCoy CE
14-9161-73 was used in Flow cytometry/Cell sorting to investigate the therapeutic potential of Arg2 enhancement via target site blockers (TSBs) in human macrophages.
Tue Sep 12 00:00:00 UTC 2023
Culture density influences the functional phenotype of human macrophages.
Frontiers in immunology
Ruder AV,Temmerman L,van Dommelen JMA,Nagenborg J,Lu C,Sluimer JC,Goossens P,Biessen EAL
14-9161-73 was used in Immunocytochemistry to demonstrate the importance of culture density for MΦ function and demand for awareness of culture density when conducting and interpreting in vitro experiments.
Tue Mar 28 00:00:00 UTC 2023
Axin1 Protects Colon Carcinogenesis by an Immune-Mediated Effect.
Cellular and molecular gastroenterology and hepatology
Sanson R,Lazzara SL,Cune D,Pitasi CL,Trentesaux C,Fraudeau M,Letourneur F,Saintpierre B,Le Gall M,Bossard P,Terris B,Finetti P,Bertucci F,Mamessier E,Romagnolo B,Perret C
14-9161-73 was used in Flow cytometry/Cell sorting to assess the role of Axin1 in normal intestinal homeostasis, with control, epithelial-specific, Axin1-knockout mice (Axin1ΔIEC) and Axin2-knockout mice and evaluate the tumor-suppressor function of Axin1 during chemically induced colorectal tumorigenesis and dextran sulfate sodium-induced colitis, and performed comparative gene expression profiling by whole-genome RNA sequencing.
Thu Feb 23 00:00:00 UTC 2023
MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma.
Cell death discovery
Yang H,Gao Y,Xu D,Xu K,Liang SQ,Yang Z,Scherz A,Hall SRR,Forster S,Berezowska S,Yao F,Ochsenbein AF,Marti TM,Kocher GJ,Schmid RA,Dorn P,Peng RW
14-9161-73 was used in Flow cytometry/Cell sorting to demonstrate that the mitogen-activated protein kinase (MAPK) pathway RAS-RAF-MEK-ERK is hyperactive and a molecular driver of MPM, independent of histological subtypes and genetic heterogeneity.
Fri Feb 10 00:00:00 UTC 2023
A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells.
Cellular and molecular life sciences : CMLS
Yin H,Karayel O,Chao YY,Seeholzer T,Hamp I,Plettenburg O,Gehring T,Zielinski C,Mann M,Krappmann D
14-9161-73 was used in Flow Cytometry to conclude that interdependent post-translational mechanisms are tightly controlling expression and activity of the A20/ABIN-1 silencing module and the cooperative action of both negative regulators is critical to balance CBM complex signaling and T cell activation.
Mon Jan 31 00:00:00 UTC 2022
Single-Cell Transcriptional Profiling Reveals Signatures of Helper, Effector, and Regulatory MAIT Cells during Homeostasis and Activation.
Journal of immunology (Baltimore, Md. : 1950)
Vorkas CK,Krishna C,Li K,Aubé J,Fitzgerald DW,Mazutis L,Leslie CS,Glickman MS
14-9161-73 was used in Flow Cytometry to present an integrated single cell transcriptomic analysis of over 76,000 human MAIT cells during early and prolonged Ag-specific activation with the MR1 ligand 5-OP-RU and nonspecific TCR stimulation.
Tue Mar 01 00:00:00 UTC 2022
Transcriptome analysis reveals the contribution of oligodendrocyte and radial glia-derived cues for maintenance of microglia identity.
Glia
Timmerman R,Zuiderwijk-Sick EA,Oosterhof N,'t Jong AEJ,Veth J,Burm SM,van Ham TJ,Bajramovic JJ
14-9161-73 was used in Flow cytometry/Cell sorting to reveal a novel role for oligodendrocyte and radial glia-derived cues in the maintenance of microglial identity, providing new anchor points to study microglia in health and disease.
Fri Apr 01 00:00:00 UTC 2022
Dynamic Interleukin-1 Receptor Type 1 Signaling Mediates Microglia-Vasculature Interactions Following Repeated Systemic LPS.
Journal of inflammation research
Nemeth DP,Liu X,McKim DB,DiSabato DJ,Oliver B,Herd A,Katta A,Negray CE,Floyd J,McGovern S,Pruden PS,Zhutang F,Smirnova M,Godbout JP,Sheridan J,Quan N
14-9161-73 was used in Flow Cytometry to identify key cellular and molecular contributors in LPS-induced neuroprotection.
Tue Jan 17 00:00:00 UTC 2023
Apelin Alleviates Meniscus Endothelial Cell Apoptosis in Osteoarthritis.
Disease markers
Lu D,Wei J,Chen J,Zhao J,Wang J,Gong Y,Wei L,Wei Q,Ban H,Li Y,Wang Z,Luo C,Zhou H,Shen J,Liao Q,He S,Zhang W,Luo Q,Xie K,Song J,Meng L
14-9161-73 was used in Flow cytometry/Cell sorting to identify two endothelial subclusters in the meniscus, featured by high expression of Homeobox A13 (HOXA13) and Ras Protein-Specific Guanine Nucleotide Releasing Factor 2 (RASGRF2), respectively.
Thu Apr 07 00:00:00 UTC 2022
Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter.
Acta neuropathologica communications
Miedema A,Gerrits E,Brouwer N,Jiang Q,Kracht L,Meijer M,Nutma E,Peferoen-Baert R,Pijnacker ATE,Wesseling EM,Wijering MHC,Gabius HJ,Amor S,Eggen BJL,Kooistra SM
14-9161-73 was used in Inhibition Assays to characterize early changes in multiple sclerosis brain tissue, identifying specific microglia and macrophage subsets at different stages of demyelinating lesions.
Fri Jan 28 00:00:00 UTC 2022
Mechanical phenotyping reveals unique biomechanical responses in retinoic acid-resistant acute promyelocytic leukemia.
iScience
Li B,Maslan A,Kitayama SE,Pierce C,Streets AM,Sohn LL
14-9161-73 was used in Flow Cytometry to investigate how different subcellular components of acute promyelocytic leukemia (APL) cells contribute to whole-cell mechanical phenotype, determining that nuclear mechanics strongly influence an APL cell's mechanical response.
Fri Feb 18 00:00:00 UTC 2022
Combining HDAC and MEK Inhibitors with Radiation against Glioblastoma-Derived Spheres.
Cells
Essien EI,Hofer TP,Atkinson MJ,Anastasov N
14-9161-73 was used in Flow cytometry/Cell sorting to suggest that combining HDAC and MEK inhibition with radiation may offer a new strategy to improve the treatment of glioblastoma.
Wed Feb 23 00:00:00 UTC 2022
Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RWd.
The Journal of biological chemistry
Lee H,Sun R,Niehrs C
14-9161-73 was used in Flow Cytometry to corroborate the function of RSPO2 as a BMP receptor antagonist and provides a proof of concept for pharmacologically uncoupling BMP antagonist from WNT agonist functions of RSPO2 using the inhibitor peptide RWd with enhanced target selectivity and limited side effects.
Tue Feb 01 00:00:00 UTC 2022
Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14.
eLife
Tomasek K,Leithner A,Glatzova I,Lukesch MS,Guet CC,Sixt M
14-9161-73 was used in flow cytometry to identify CD14, the major co-receptor for lipopolysaccharide detection, on mouse dendritic cells (DCs) as a binding partner of FimH, the protein located at the tip of the type 1 pilus of Escherichia coli.
Tue Jul 26 00:00:00 UTC 2022
CIITA promoter polymorphism impairs monocytes HLA-DR expression in patients with septic shock.
iScience
Miatello J,Lukaszewicz AC,Carter MJ,Faivre V,Hua S,Martinet KZ,Bourgeois C,Quintana-Murci L,Payen D,Boniotto M,Tissières P
14-9161-73 was used in Flow cytometry/Cell sorting to demonstrate that G-286A*rs3087456 significantly impact mHLA-DR expression in patients with septic shock in part through CIITA promoter III activity, that can be rescued using IFN-γ.
Fri Nov 18 00:00:00 UTC 2022
Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.
Science advances
Poh AR,Love CG,Chisanga D,Steer JH,Baloyan D,Chopin M,Nutt S,Rautela J,Huntington ND,Etemadi N,O'Brien M,O'Keefe R,Ellies LG,Macri C,Mintern JD,Whitehead L,Gangadhara G,Boon L,Chand AL,Lowell CA,Shi W,Pixley FJ,Ernst M
14-9161-73 was used in Flow cytometry/Cell sorting to suggest that therapeutic targeting of HCK activity enhances response to immunotherapy by simultaneously stimulating immune cell activation and inhibiting the immunosuppressive tumor microenvironment.
Fri Jun 24 00:00:00 UTC 2022
Comprehensive characterization of the postoperative pericardial inflammatory response: Potential implications for clinical outcomes.
JTCVS open
Fatehi Hassanabad A,Schoettler FI,Kent WDT,Adams CA,Holloway DD,Ali IS,Novick RJ,Ahsan MR,McClure RS,Shanmugam G,Kidd WT,Kieser TM,Fedak PWM,Deniset JF
14-9161-73 was used in Flow cytometry/Cell sorting to provide a comprehensive assessment of the local postoperative inflammatory response.
Thu Dec 01 00:00:00 UTC 2022
Analysis of Peripheral Blood Basophils in Pediatric Systemic Lupus Erythematosus.
Diagnostics (Basel, Switzerland)
Dossybayeva K,Bexeitov Y,Mukusheva Z,Almukhamedova Z,Assylbekova M,Abdukhakimova D,Rakhimzhanova M,Poddighe D
14-9161-73 was used in Flow cytometry/Cell sorting to assess circulating basophils in children affected with pediatric SLE (pSLE).
Tue Jul 12 00:00:00 UTC 2022
Trained Immunity Provides Long-Term Protection against Bacterial Infections in Channel Catfish.
Pathogens (Basel, Switzerland)
Petrie-Hanson L,Peterman AEB
14-9161-73 was used in Flow cytometry/Cell sorting to design prophylactic and non-antibiotic based therapies and develop broad-based vaccines to limit bacterial disease outbreaks in catfish production.
Sun Oct 02 00:00:00 UTC 2022
Engineering pan-HIV-1 neutralization potency through multispecific antibody avidity.
Proceedings of the National Academy of Sciences of the United States of America
Rujas E,Cui H,Burnie J,Aschner CB,Zhao T,Insausti S,Muthuraman K,Semesi A,Ophel J,Nieva JL,Seaman MS,Guzzo C,Treanor B,Julien JP
14-9161-73 was used in Inhibition Assays to show that this robust plug-and-play antibody design is relevant against indications where multispecificity and avidity are leveraged simultaneously to mediate optimal biological activity.
Tue Jan 25 00:00:00 UTC 2022
Downregulation of SATB1 by miRNAs reduces megakaryocyte/erythroid progenitor expansion in preclinical models of Diamond-Blackfan anemia.
Experimental hematology
Wilkes MC,Scanlon V,Shibuya A,Cepika AM,Eskin A,Chen Z,Narla A,Glader B,Roncarolo MG,Nelson SF,Sakamoto KM
14-9161-73 was used in Flow Cytometry to determine the chromatin regulator, SATB1 was prematurely downregulated through the coordinated action of upregulated miR-34 and miR-30 during differentiation in ribosomal insufficiency.
Fri Jul 01 00:00:00 UTC 2022
Tumor Growth Remains Refractory to Myc Ablation in Host Macrophages.
Cells
Morrow RJ,Allam AH,Konecnik J,Baloyan D,Dijkstra C,Eissmann MF,Jacob SP,O'Brien M,Poh AR,Ernst M
14-9161-73 was used in Flow Cytometry to benchmark Myc inactivation in tumor cells against the contribution of its expression in myeloid cells of murine hosts that harbor endogenous or allograft tumors.
Sat Dec 17 00:00:00 UTC 2022
Targeted immunotherapy for HER2-low breast cancer with 17p loss.
Science translational medicine
Li Y,Sun Y,Kulke M,Hechler T,Van der Jeught K,Dong T,He B,Miller KD,Radovich M,Schneider BP,Pahl A,Zhang X,Lu X
14-9161-73 was used in Flow cytometry/Cell sorting to conclude that 17p loss not only drives breast tumorigenesis but also confers therapeutic vulnerabilities that may be used to develop targeted precision immunotherapy.
Wed Feb 10 00:00:00 UTC 2021
A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy.
Cancer immunology research
Liu SQ,Grantham A,Landry C,Granda B,Chopra R,Chakravarthy S,Deutsch S,Vogel M,Russo K,Seiss K,Tschantz WR,Rejtar T,Ruddy DA,Hu T,Aardalen K,Wagner JP,Dranoff G,D'Alessio JA
14-9161-73 was used in Flow Cytometry to reveal multiple mechanisms that can be targeted to enhance the clinical potential of current and future T-cell-engaging CD3-bispecific antibody therapies.
Fri Jan 01 00:00:00 UTC 2021
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.
Aging cell
Webb LMC,Fra-Bido S,Innocentin S,Matheson LS,Attaf N,Bignon A,Novarino J,Fazilleau N,Linterman MA
14-9161-73 was used in Flow Cytometry to show increased formation of Tfh precursors (pre-Tfh) but no associated increase in germinal centre (GC)-Tfh cells in aged mice, suggesting age-driven promotion of only early Tfh cell differentiation.
Fri Jan 01 00:00:00 UTC 2021
Type 2 diabetes is associated with impaired jejunal enteroendocrine GLP-1 cell lineage in human obesity.
International journal of obesity (2005)
Osinski C,Le Gléau L,Poitou C,de Toro-Martin J,Genser L,Fradet M,Soula HA,Leturque A,Blugeon C,Jourdren L,Hubert EL,Clément K,Serradas P,Ribeiro A
14-9161-73 was used in Flow Cytometry to study the transcriptional profiles of enteroendocrine cells from obese or type 2 diabetic patients.
Fri Jan 01 00:00:00 UTC 2021
RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia.
Cell reports
Sun R,He L,Lee H,Glinka A,Andresen C,Hübschmann D,Jeremias I,Müller-Decker K,Pabst C,Niehrs C
14-9161-73 was used in Flow cytometry/Cell sorting to indicate that in AML, RSPO2 acts as an autocrine BMP antagonist to promote cancer cell renewal and may serve as a marker for poor prognosis.
Tue Aug 17 00:00:00 UTC 2021
The active component of ginseng, ginsenoside Rb1, improves erythropoiesis in models of Diamond-Blackfan anemia by targeting Nemo-like kinase.
The Journal of biological chemistry
Wilkes MC,Jung K,Lee BE,Saxena M,Sathianathen RS,Mercado JD,Perez C,Flygare J,Narla A,Glader B,Sakamoto KM
14-9161-73 was used in Flow Cytometry to report that the active component of ginseng, ginsenoside Rb1, suppresses NLK expression and improves erythropoiesis in in vitro models of DBA.
Wed Sep 01 00:00:00 UTC 2021
IFNγ-producing NK cells in adipose tissue are associated with hyperglycemia and insulin resistance in obese women.
International journal of obesity (2005)
Mogilenko DA,Caiazzo R,L'homme L,Pineau L,Raverdy V,Noulette J,Derudas B,Pattou F,Staels B,Dombrowicz D
14-9161-73 was used in Flow cytometry/Cell sorting to suggest that a distinct IFNγ-producing NK cell subset is involved in metabolic homeostasis in visceral AT in humans with obesity and may be a potential target for therapy of IR.
Thu Jul 01 00:00:00 UTC 2021
NAD Modulates DNA Methylation and Cell Differentiation.
Cells
Ummarino S,Hausman C,Gaggi G,Rinaldi L,Bassal MA,Zhang Y,Seelam AJ,Kobayashi IS,Borchiellini M,Ebralidze AK,Ghinassi B,Trinh BQ,Kobayashi SS,Di Ruscio A
14-9161-73 was used in Flow Cytometry to present a novel epigenetic effect of the essential nutrient NAD.
Tue Nov 02 00:00:00 UTC 2021
Suppression of Human Dendritic Cells by Regulatory T Cells.
Bio-protocol
Huang Q,Lam AJ,Boardman DA,Dawson NAJ,Levings MK
14-9161-73 was used in Flow Cytometry to measure human Treg-mediated suppression of CD80 and CD86 expression on mature, monocyte-derived dendritic cells.
Fri Nov 05 00:00:00 UTC 2021
Circulating p16-Positive and p16-Negative Tumor Cells Serve as Independent Prognostic Indicators of Survival in Patients with Head and Neck Squamous Cell Carcinomas.
Journal of personalized medicine
Chang PH,Wang HM,Kuo YC,Lee LY,Liao CJ,Kuo HC,Hsu CL,Liao CT,Lin SH,Huang PW,Wu TM,Hsieh JC
14-9161-73 was used in Flow Cytometry to help stratify the risk and prognosis before chemoradiotherapy in clinical practice and enable us to perform de-intensifying therapies.
Sun Nov 07 00:00:00 UTC 2021
Transcriptome Profiling Reveals B-Lineage Cells Contribute to the Poor Prognosis and Metastasis of Clear Cell Renal Cell Carcinoma.
Frontiers in oncology
Yang F,Zhao J,Luo X,Li T,Wang Z,Wei Q,Lu H,Meng Y,Cai K,Lu L,Lu Y,Chen L,Sooranna SR,Luo L,Song J,Meng L
14-9161-73 was used in Flow cytometry/Cell sorting to explore the pathological roles of B-lineage cells in clear cell renal cell carcinoma (ccRCC) and investigate whether targeting the pro-metastatic immune cell in the ccRCC microenvironment could reduce the proportion of ccRCC patients who continue to progress to metastasis after immune therapy.
Tue Sep 07 00:00:00 UTC 2021
A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics.
Nature medicine
Langenberg MCC,Hoogerwerf MA,Koopman JPR,Janse JJ,Kos-van Oosterhoud J,Feijt C,Jochems SP,de Dood CJ,van Schuijlenburg R,Ozir-Fazalalikhan A,Manurung MD,Sartono E,van der Beek MT,Winkel BMF,Verbeek-Menken PH,Stam KA,van Leeuwen FWB,Meij P,van Diepen A,van Lieshout L,van Dam GJ,Corstjens PLAM,Hokke CH,Yazdanbakhsh M,Visser LG,Roestenberg M
14-9161 was used in Flow cytometry/Cell sorting to performed a dose-escalating clinical safety trial in 17 volunteers with male Schistosoma mansoni cercariae, which do not produce eggs (clinicaltrials.gov NCT02755324), at the Leiden University Medical Center, the Netherlands.
Sun Mar 01 00:00:00 UTC 2020
Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity.
Cell stem cell
Zhu H,Blum RH,Bernareggi D,Ask EH,Wu Z,Hoel HJ,Meng Z,Wu C,Guan KL,Malmberg KJ,Kaufman DS
14-9161-73 was used in Flow Cytometry to demonstrate that CIS plays a key role to regulate human NK cell metabolic activity and thereby modulate anti-tumor activity.
Thu Aug 06 00:00:00 UTC 2020
Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model.
The Journal of experimental medicine
Wang S,Mustafa M,Yuede CM,Salazar SV,Kong P,Long H,Ward M,Siddiqui O,Paul R,Gilfillan S,Ibrahim A,Rhinn H,Tassi I,Rosenthal A,Schwabe T,Colonna M
14-9161 was used in Flow cytometry/Cell sorting to examine the impact of an TREM2 agonistic antibody on Aß plaques and tißue damage within a mouse Alzheimer's model.
Mon Sep 07 00:00:00 UTC 2020
Pan-SHIP1/2 inhibitors promote microglia effector functions essential for CNS homeostasis.
Journal of cell science
Pedicone C,Fernandes S,Dungan OM,Dormann SM,Viernes DR,Adhikari AA,Choi LB,De Jong EP,Chisholm JD,Kerr WG
14-9161 was used in Flow cytometry/Cell sorting to test the capacity of SHIP1-selective, SHIP2-selective and pan-SHIP1/2 inhibitors for their ability to impact on microglia proliferation, lysosomal compartment size and phagocytic function.
Fri Jan 10 00:00:00 UTC 2020
Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients.
Mediators of inflammation
Samarani S,Sagala P,Jantchou P,Grimard G,Faure C,Deslandres C,Amre DK,Ahmad A
14-9161-73 was used in Flow cytometry/Cell sorting to investigate activation status, cytotoxic potential, and gut homing ability of the peripheral blood Natural Killer (NK) cells in Crohn disease (CD) patients.
Fri Dec 11 00:00:00 UTC 2020
Automated Data Cleanup for Mass Cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Bagwell CB,Inokuma M,Hunsberger B,Herbert D,Bray C,Hill B,Stelzer G,Li S,Kollipara A,Ornatsky O,Baranov V
14-9161-73 was used in Flow cytometry/Cell sorting to describe a probability state modeling (PSM) method that automatically identifies and removes these elements, resulting in FCS files that contain mostly live and intact events.
Sat Feb 01 00:00:00 UTC 2020
Umbilical Cord Blood and iPSC-Derived Natural Killer Cells Demonstrate Key Differences in Cytotoxic Activity and KIR Profiles.
Frontiers in immunology
Goldenson BH,Zhu H,Wang YM,Heragu N,Bernareggi D,Ruiz-Cisneros A,Bahena A,Ask EH,Hoel HJ,Malmberg KJ,Kaufman DS
14-9161-73 was used in Mass Spectrometry to find CD56+ NK cells isolated and expanded directly from umbilical cord blood (UCB56) and NK cells derived from CD34+ hematopoietic stem/progenitors in umbilical cord blood (UCB34) differ in their expression of markers associated with differentiation including CD16, CD2, and killer Ig-like receptors.
Mon May 03 00:00:00 UTC 2021
SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.
Cell reports
Davenne T,Klintman J,Sharma S,Rigby RE,Blest HTW,Cursi C,Bridgeman A,Dadonaite B,De Keersmaecker K,Hillmen P,Chabes A,Schuh A,Rehwinkel J
14-9161 was used in Flow Cytometry to propose to use forodesine as a precision medicine for leukemia, stratifying patients by SAMHD1 genotype or expression.
Tue May 12 00:00:00 UTC 2020
Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.
Nature communications
Wilkes MC,Siva K,Chen J,Varetti G,Youn MY,Chae H,Ek F,Olsson R,Lundbäck T,Dever DP,Nishimura T,Narla A,Glader B,Nakauchi H,Porteus MH,Repellin CE,Gazda HT,Lin S,Serrano M,Flygare J,Sakamoto KM
14-9161 was used in Flow cytometry/Cell sorting to report the identification of Nemo-like kinase (NLK) as a potential target for DBA therapy.
Fri Jul 03 00:00:00 UTC 2020
Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis.
Immunity
Deniset JF,Belke D,Lee WY,Jorch SK,Deppermann C,Hassanabad AF,Turnbull JD,Teng G,Rozich I,Hudspeth K,Kanno Y,Brooks SR,Hadjantonakis AK,O'Shea JJ,Weber GF,Fedak PWM,Kubes P
14-9161-73 was used in Blocking experiments to find that disruption of the pericardial cavity accelerated maladaptive post-MI cardiac remodeling.
Tue Jul 16 00:00:00 UTC 2019
Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis.
Science translational medicine
Rosen DA,Seki SM,Fernández-Castañeda A,Beiter RM,Eccles JD,Woodfolk JA,Gaultier A
14-9161-73 was used in Flow cytometry/Cell sorting to identify the endoplasmic reticulum-resident protein sigma-1 receptor as an essential inhibitor of cytokine production in a preclinical model of septic shock.
Wed Feb 06 00:00:00 UTC 2019
An altered response in macrophage phenotype following damage in aged human skeletal muscle: implications for skeletal muscle repair.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Sorensen JR,Kaluhiokalani JP,Hafen PS,Deyhle MR,Parcell AC,Hyldahl RD
14-9161 was used in Flow cytometry/Cell sorting to test the hypothesis that macrophage polarisation is altered in old compared to young skeletal muscle, possibly contributing to the poor satellite cell response observed in older muscle tissue.
Sun Sep 01 00:00:00 UTC 2019
GPER activation protects against epithelial barrier disruption by Staphylococcus aureus α-toxin.
Scientific reports
Triplett KD,Pokhrel S,Castleman MJ,Daly SM,Elmore BO,Joyner JA,Sharma G,Herbert G,Campen MJ,Hathaway HJ,Prossnitz ER,Hall PR
14-9161 was used in Flow cytometry/Cell sorting to develop and test a novel DNA vaccine for Mayaro virus which encodes a synthetically designed consensus Mayaro envelope sequence.
Mon Feb 04 00:00:00 UTC 2019
LRRC25 plays a key role in all-trans retinoic acid-induced granulocytic differentiation as a novel potential leukocyte differentiation antigen.
Protein & cell
Liu W,Li T,Wang P,Liu W,Liu F,Mo X,Liu Z,Song Q,Lv P,Ruan G,Han W
14-9161 was used in Flow cytometry/Cell sorting to study the role of LRRC25 in regulating all-trans retinoic acid-induced granulocytic differentiation.
Sat Sep 01 00:00:00 UTC 2018
A flow cytometry-based assay to determine the phagocytic activity of both clinical and nonclinical antibody samples against Chlamydia trachomatis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Grasse M,Rosenkrands I,Olsen A,Follmann F,Dietrich J
14-9161 was used in Flow cytometry/Cell sorting to developed a simple and rapid flow cytometry based assay to measure the capacity of antibodies to mediate Fc-receptor dependent phagocytosis.
Tue May 01 00:00:00 UTC 2018
PDL-1 Blockade Prevents T Cell Exhaustion, Inhibits Autophagy, and Promotes Clearance of Leishmania donovani.
Infection and immunity
Habib S,El Andaloussi A,Elmasry K,Handoussa A,Azab M,Elsawey A,Al-Hendy A,Ismail N
14-9161 was used in Flow cytometry/Cell sorting to examine the role of PD1/PDL-1 in the pathogenesis of visceral leishmaniasis.
Fri Jun 01 00:00:00 UTC 2018
Distribution of circulating follicular helper T cells and expression of interleukin-21 and chemokine C-X-C ligand 13 in gastric cancer.
Oncology letters
Meng X,Yu X,Dong Q,Xu X,Li J,Xu Q,Ma J,Zhou C
14-9161-73 was used in Flow cytometry/Cell sorting to investigate the distribution of cTfh cells, and the expression of IL-21 and CXCL13 in patients with gastric cancer was evaluated in order to ascertain the significance and potential mechanisms of these effectors in gastric cancer.
Sat Sep 01 00:00:00 UTC 2018
PD1 is expressed on exhausted T cells as well as virus specific memory CD8+ T cells in the bone marrow of myeloma patients.
Oncotarget
Sponaas AM,Yang R,Rustad EH,Standal T,Thoresen AS,Dao Vo C,Waage A,Slørdahl TS,Børset M,Sundan A
14-9161 was used in Flow cytometry/Cell sorting to study the expression of PD-1 on exhausted T cells as well as virus specific memory CD8+ T cells in the bone marrow of myeloma patients.
Fri Aug 10 00:00:00 UTC 2018
Identification of Chemotherapy-Induced Leukemic-Regenerating Cells Reveals a Transient Vulnerability of Human AML Recurrence.
Cancer cell
Boyd AL,Aslostovar L,Reid J,Ye W,Tanasijevic B,Porras DP,Shapovalova Z,Almakadi M,Foley R,Leber B,Xenocostas A,Bhatia M
14-9161-73 was used in Flow cytometry/Cell sorting to demonstrate that LRC features can be used as markers of relapse and are therapeutically targetable to prevent disease recurrence.
Mon Sep 10 00:00:00 UTC 2018
miR-210 Enhances the Therapeutic Potential of Bone-Marrow-Derived Circulating Proangiogenic Cells in the Setting of Limb Ischemia.
Molecular therapy : the journal of the American Society of Gene Therapy
Besnier M,Gasparino S,Vono R,Sangalli E,Facoetti A,Bollati V,Cantone L,Zaccagnini G,Maimone B,Fuschi P,Da Silva D,Schiavulli M,Aday S,Caputo M,Madeddu P,Emanueli C,Martelli F,Spinetti G
14-9161-73 was used in Flow Cytometry to provide new mechanistic evidences for a role of miR-210 in PACs.
Thu Jul 05 00:00:00 UTC 2018
PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin.
Scientific reports
Miao X,Xu R,Fan B,Chen J,Li X,Mao W,Hua S,Li B
14-9161-73 was used in Flow Cytometry to indicate that PD-L1 protein therapy inhibits the immune response and reverses depigmentation development in Pmel-1 vitiligo mice.
Thu Jan 25 00:00:00 UTC 2018
Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy.
Oncogene
Zhu B,Tang L,Chen S,Yin C,Peng S,Li X,Liu T,Liu W,Han C,Stawski L,Xu ZX,Zhou G,Chen X,Gao X,Goding CR,Xu N,Cui R,Cao P
14-9161-73 was used in Flow cytometry/Cell sorting to identify a critical and targetable PD-L1 upstream regulator and provide an alternative strategy to inhibit the PD-1/PD-L1 signaling in melanoma treatment.
Sat Sep 01 00:00:00 UTC 2018
Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy.
Oncogene
Zhu B,Tang L,Chen S,Yin C,Peng S,Li X,Liu T,Liu W,Han C,Stawski L,Xu ZX,Zhou G,Chen X,Gao X,Goding CR,Xu N,Cui R,Cao P
14-9161-73 was used in Flow cytometry/Cell sorting to identify a critical and targetable PD-L1 upstream regulator and provide an alternative strategy to inhibit the PD-1/PD-L1 signaling in melanoma treatment.
Sat Sep 01 00:00:00 UTC 2018
Genetic ataxia telangiectasia porcine model phenocopies the multisystemic features of the human disease.
Biochimica et biophysica acta. Molecular basis of disease
Beraldi R,Meyerholz DK,Savinov A,Kovács AD,Weimer JM,Dykstra JA,Geraets RD,Pearce DA
14-9161-73 was used in Flow cytometry/Cell sorting to demonstrate that ataxia telangiectasia mutated-/- female pigs are infertile, with anatomical and functional signs of an immature reproductive system.
Wed Nov 01 00:00:00 UTC 2017
Calreticulin is an effective immunologic adjuvant to tumor-associated antigens.
Experimental and therapeutic medicine
Wang J,Gao ZP,Qin S,Liu CB,Zou LL
14-9161-73 was used in Flow Cytometry to examine whether calreticulin is able to act as an immunologic adjuvant and translocate itself and tumour-associated antigens to the cell surface to induce a specific anti-tumour immune response.
Sun Oct 01 00:00:00 UTC 2017
Multi-Surface Antigen Staining of Larger Extracellular Vesicles.
Methods in molecular biology (Clifton, N.J.)
Lukacs-Kornek V,Julich-Haertel H,Urban SK,Kornek M
14-9161-73 was used in Flow Cytometry to describe in detail the needed steps as currently done in our laboratory.
Thu May 03 00:00:00 UTC 2018
OX40, PD-1 and CTLA-4 are selectively expressed on tumor-infiltrating T cells in head and neck cancer.
Clinical & translational immunology
Montler R,Bell RB,Thalhofer C,Leidner R,Feng Z,Fox BA,Cheng AC,Bui TG,Tucker C,Hoen H,Weinberg A
14-9161 was used in Blocking experiments to suggest that there may be therapeutic advantages of targeting these pathways independently or in combination for patients with this disease.
Fri Apr 01 00:00:00 UTC 2016
G-CSF regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer.
Oncoimmunology
Hollmén M,Karaman S,Schwager S,Lisibach A,Christiansen AJ,Maksimow M,Varga Z,Jalkanen S,Detmar M
14-9161 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms by which tumour-associated macrophages promote breast cancer growth and metastasis, showing that G-CSF regulates macrophage phenotype and is associated with poor survival.
Tue Mar 01 00:00:00 UTC 2016
Comparative miRNA-Based Fingerprinting Reveals Biological Differences in Human Olfactory Mucosa- and Bone-Marrow-Derived Mesenchymal Stromal Cells.
Stem cell reports
Lindsay SL,Johnstone SA,McGrath MA,Mallinson D,Barnett SC
14-9161 was used in Flow cytometry/Cell sorting to investigate the biological differences in human olfactory mucosa- and bone-marrow-derived mesenchymal stromal cells.
Tue May 10 00:00:00 UTC 2016
Single-cell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Han L,Qiu P,Zeng Z,Jorgensen JL,Mak DH,Burks JK,Schober W,McQueen TJ,Cortes J,Tanner SD,Roboz GJ,Kantarjian HM,Kornblau SM,Guzman ML,Andreeff M,Konopleva M
14-9161 was used in Flow cytometry/Cell sorting to evaluate intracellular signaling in antigen-defined stem/progenitor cell subsets in primary AML.
Wed Apr 01 00:00:00 UTC 2015
Semi-automated and standardized cytometric procedures for multi-panel and multi-parametric whole blood immunophenotyping.
Clinical immunology (Orlando, Fla.)
Hasan M,Beitz B,Rouilly V,Libri V,Urrutia A,Duffy D,Cassard L,Di Santo JP,Mottez E,Quintana-Murci L,Albert ML,Rogge L
14-9161-73 was used in Flow cytometry/Cell sorting to develop a robust protocol that enables semi-automated eight-color cytometric immunophenotyping.
Wed Apr 01 00:00:00 UTC 2015
Altered translation of GATA1 in Diamond-Blackfan anemia.
Nature medicine
Ludwig LS,Gazda HT,Eng JC,Eichhorn SW,Thiru P,Ghazvinian R,George TI,Gotlib JR,Beggs AH,Sieff CA,Lodish HF,Lander ES,Sankaran VG
14-9161 was used in Flow cytometry/Cell sorting to study the altered translation of GATA1 in cells isolated from patients with Diamond-Blackfan anemia.
Tue Jul 01 00:00:00 UTC 2014
TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors.
Blood
Bibikova E,Youn MY,Danilova N,Ono-Uruga Y,Konto-Ghiorghi Y,Ochoa R,Narla A,Glader B,Lin S,Sakamoto KM
14-9161 was used in Flow cytometry/Cell sorting to demonstrate that GATA1 is downregulated in RPS19-deficient cells and zebrafish through upregulation of p53, TNF-a, and p38 MAPK.
Thu Dec 11 00:00:00 UTC 2014
Elongated membrane tethers, individually anchored by high affinity α4β1/VCAM-1 complexes, are the quantal units of monocyte arrests.
PloS one
Chu C,Celik E,Rico F,Moy VT
14-9161 was used in Flow cytometry/Cell sorting to investigate the mechanisms involved in the adhesion of THP-1 cells to immobilised VCAM-1.
Mon Dec 16 00:00:00 UTC 2013
