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Invitrogen
FAM84A Polyclonal Antibody
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Product Details
PA5-61571
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FAM84A. Recombinant protein control fragment (Product #RP-98523).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2641474
Product Specific Information
Immunogen sequence: PSGIEKDELR VGVAYFFSDD EEDLDERGQP DKFGVKAPPG CTPCPESPSR HHHHLLHQLV LNETQFSAFR GQECIFSKVS GGP
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Target Information
The FAM84A gene, also known as Family With Sequence Similarity 84 Member A, is located on chromosome 1q21.3. This gene encodes a protein that has been implicated in the development and progression of various cancers. In particular, FAM84A has been identified as a key player in the epithelial-mesenchymal transition (EMT) and Wnt/beta-catenin signaling pathways, which are crucial for tumor development and metastasis. Studies have shown that the downregulation of FAM84A can inhibit thyroid cancer progression while being negatively regulated by the tumor suppressor miR-874-3p. Additionally, FAM84A has been noted to be over-expressed in phenobarbital-promoted mouse liver tumors, indicating its potential role in chemical carcinogenesis. The gene's expression is regulated by nuclear receptor CAR, highlighting its involvement in liver cancer pathophysiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: family with sequence similarity 84, member A; LRAT domain-containing 1; Neurologic sensory protein 1; neurological/sensory 1; NSE1; Protein FAM84A; Protein LRATD1
Gene Aliases: FAM84A; LRATD1; NSE1; PP11517
UniProt ID: (Human) Q96KN4
Entrez Gene ID: (Human) 151354
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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