Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
DcTRAILR2 Monoclonal Antibody (263310)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
MA5-23964
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
263310
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse DcTRAIL R2/TNFRSF22 Ala39-Arg175
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2605563
Product Specific Information
In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse (rm) 4-1BB, rmBAFF R, rmCD27, rmCD30, rmCD40, rmDcTRAIL R1, rmDR3, rmEDAR, rmFas, rmGITR, rmHVEM, rmLT beta R, rmNGF R, rmOPG, rmOX40, rmRANK, rmTNF RI, and rmTNF RII is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
DcTRAILR2, also known as decoy receptor TRAIL receptor 2 (DcR2), is encoded by the TNFRSF10D gene and is part of the tumor necrosis factor receptor superfamily. This receptor is characterized by its ability to bind to the TNF-related apoptosis-inducing ligand (TRAIL) without inducing apoptosis, thereby serving as a decoy receptor. DcTRAILR2 plays a crucial role in regulating apoptosis by inhibiting TRAIL-mediated signaling pathways that lead to cell death. Expressed in various tissues, it contributes to immune modulation by protecting cells from apoptosis, which is particularly relevant in cancer biology where it can influence tumor cell survival and resistance to apoptosis-based therapies. DcTRAILR2's role in apoptosis regulation makes it significant in pathological conditions involving abnormal cell proliferation and survival, such as cancer and autoimmune diseases. Research efforts continue to explore the therapeutic potentials of targeting TRAIL receptors to enhance the efficacy of cancer treatments and to understand their broader implications in immune regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Decoy TRAIL receptor 2; TNF receptor family member SOBa; TNF receptor homolog 2; Tumor necrosis factor receptor p60 homolog 2; Tumor necrosis factor receptor superfamily member 22; tumor necrosis factor receptor superfamily, member 1a-like 2
Gene Aliases: 2810028K06Rik; C130035G06Rik; Dctrailr2; mDcTrailr2; SOBa; Tnfrh2; Tnfrsf1al2; Tnfrsf22
UniProt ID: (Mouse) Q9ER62
Entrez Gene ID: (Mouse) 79202
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support