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Immunogen sequence: AIANSLHNSK DLSKDQHGRN CLLASYVHYV FRLPEVQRDV PKSGAPTALL DPRSYHTYGR TSAAAVSSKL LQARVMSSSN PDLAGTHSAA DEEVKNIMSS KIADRNCSRM SYYCSGSSDA PSS
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 87%.
The Dedicator of cytokinesis protein 8 (DOCK8) is a member of the DOCK180 family of guanine nucleotide exchange factors. DOCK8 plays an essential role in humoral immune responses and is important in the proper formation of the B cell immunological synapse. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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