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Invitrogen
DOCK10 Polyclonal Antibody
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Product Details
PA5-57385
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DOCK10
Conjugate
Form
Liquid
Concentration
Lot-Specific
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2640735
Product Specific Information
Immunogen sequence: MLLDNMPRIY LKDLYPFTVN TSNQGSRDDL STNGGFQSQT AIKHANSVDT SFSKDVLNSI AAFSSIAIST VNHADSRASL ASLDSNPSTN EK
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Target Information
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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