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PA1-25000 detects DIAPH1 from human samples. PA1-25000 is expected to cross react with mouse due to sequence homology.
PA1-25000 has been successfully used in Western blot procedures.
The PA1-25000 immunogen is a synthetic peptide corresponding to a portion of the human diaphanous homolog 1 encoded within exon 27.
This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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